Cortical response states for enhanced sensory discrimination.
Cortical response states for enhanced sensory discrimination.
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DOI：
10.7554/elife.29226
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发表时间：
2017-12-23
期刊：
影响因子：
7.7
通讯作者：
Dragoi V
中科院分区：
文献类型：
--
作者：
Gutnisky DA;Beaman C;Lew SE;Dragoi V
清醒时大脑活动的特点是神经元反应的快速波动。这些波动是否在调节行为反应的准确性方面发挥了任何作用，人们对此知之甚少。在这里，我们调查了是否以及如何在人口反应的审判变化影响猴子V1和知觉性能的感觉编码。虽然单个神经元的反应在试验中变化很大，但许多细胞倾向于与当地群体共变。当群体活动处于“低”状态时，神经元的诱发反应和相关变异性较低，但预测感知准确性的概率较高。放电率波动对网络和感知准确性的影响在刺激呈现前200 ms最强，当用于测量群体状态的细胞数量减少时，其影响大大减小。这些研究结果表明，增强知觉歧视发生时，人口活动是在一个“沉默”的反应模式，其中神经元增加信息提取。
Brain activity during wakefulness is characterized by rapid fluctuations in neuronal responses. Whether these fluctuations play any role in modulating the accuracy of behavioral responses is poorly understood. Here, we investigated whether and how trial changes in the population response impact sensory coding in monkey V1 and perceptual performance. Although the responses of individual neurons varied widely across trials, many cells tended to covary with the local population. When population activity was in a ‘low’ state, neurons had lower evoked responses and correlated variability, yet higher probability to predict perceptual accuracy. The impact of firing rate fluctuations on network and perceptual accuracy was strongest 200 ms before stimulus presentation, and it greatly diminished when the number of cells used to measure the state of the population was decreased. These findings indicate that enhanced perceptual discrimination occurs when population activity is in a ‘silent’ response mode in which neurons increase information extraction.