MITOCHONDRIAL-DNA IS A MAJOR CELLULAR TARGET FOR A DIHYDRODIOL-EPOXIDE DERIVATIVE OF BENZO[A]PYRENE
MITOCHONDRIAL-DNA IS A MAJOR CELLULAR TARGET FOR A DIHYDRODIOL-EPOXIDE DERIVATIVE OF BENZO[A]PYRENE
复制标题
DOI：
10.1126/science.6770466
复制
发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
WEINSTEIN, IB
中科院分区：
文献类型：
--
作者：
BACKER, JM;WEINSTEIN, IB
当哺乳动物细胞培养物暴露于（±）-7，8 α-二羟基-9 α，10 α-环氧-7，8，9，10-四氢苯并[a]芘（一种苯并[a]芘的致突变和致癌衍生物）2小时时，线粒体DNA的共价修饰程度是核DNA的40至90倍。有证据表明，这反映了衍生物的亲脂性和线粒体中脂质与DNA的比例非常高。这些结果表明，线粒体DNA可能是化学致癌物的一个重要的细胞靶点。
When mammalian cell cultures are exposed for 2 hours to (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modification of mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. Evidence is presented that this reflects the lipophilic character of the derivative and the very high ratio of lipid to DNA in mitochondria. These results suggest that mitochondrial DNA may be an important cellular target of chemical carcinogens.