A/T/(N) Profile in Cerebrospinal Fluid of Parkinson's Disease with/without Cognitive Impairment and Dementia with Lewy Bodies.
A/T/(N) Profile in Cerebrospinal Fluid of Parkinson's Disease with/without Cognitive Impairment and Dementia with Lewy Bodies.
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DOI：
10.3390/diagnostics10121015
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发表时间：
2020-11-26
期刊：
影响因子：
--
通讯作者：
Parnetti L
中科院分区：
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作者：
Bellomo G;Paolini Paoletti F;Chipi E;Petricciuolo M;Simoni S;Tambasco N;Parnetti L
神经病理学研究报告，在伴有痴呆的突触核蛋白病，即伴有痴呆的帕金森病（PD）（PDD）和伴有路易体的痴呆（DLB）中，经常观察到阿尔茨海默病（AD）的组织病理学标志，特别是淀粉样蛋白斑块。在这项研究中，我们调查了脑脊液（CSF）AD生物标志物在不同的临床表型的突触核蛋白病。在98例PD（48例轻度认知功能障碍，PD-MCI; 50例认知功能未受损，PD-nMCI）、14例PDD和15例DLB患者以及48例神经系统对照（CTRL）中，分别测量CSF Aβ42/Aβ40比值、磷酸化tau和总tau作为淀粉样变性（A）、tau病变（T）和神经变性（N）的标志物。在我们的研究中，CTRL、PD-MCI和PD-nMCI患者之间的CSF AD生物标志物无显著差异。在PD-nMCI和PD-MCI组中，A-/T-/N-图谱最具代表性。PD-nMCI和PD-MCI的A+患病率相似（分别为10%和13%），PDD（64%）和DLB（73%）的患病率较高。DLB显示Aβ42/Aβ40比值最低。基线时较高的总tau蛋白预测PD-MCI患者1年后的神经心理学结局较差。A+/T+，即，AD样CSF特征在DLB组中最常见（40% vs. PDD中29%）。
Neuropathological investigations report that in synucleinopathies with dementia, namely Parkinson’s disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB), the histopathological hallmarks of Alzheimer’s Disease (AD), in particular amyloid plaques, are frequently observed. In this study, we investigated the cerebrospinal fluid (CSF) AD biomarkers in different clinical phenotypes of synucleinopathies. CSF Aβ42/Aβ40 ratio, phosphorylated tau and total tau were measured as markers of amyloidosis (A), tauopathy (T) and neurodegeneration (N) respectively, in 98 PD (48 with mild cognitive impairment, PD-MCI; 50 cognitively unimpaired, PD-nMCI), 14 PDD and 15 DLB patients, and 48 neurological controls (CTRL). In our study, CSF AD biomarkers did not significantly differ between CTRL, PD-MCI and PD-nMCI patients. In PD-nMCI and PD-MCI groups, A-/T-/N- profile was the most represented. Prevalence of A+ was similar in PD-nMCI and PD-MCI (10% and 13%, respectively), being higher in PDD (64%) and in DLB (73%). DLB showed the lowest values of Aβ42/Aβ40 ratio. Higher total tau at baseline predicted a worse neuropsychological outcome after one year in PD-MCI. A+/T+, i.e., AD-like CSF profile, was most frequent in the DLB group (40% vs. 29% in PDD).