Lateralized Deficits of Disgust Processing After Insula-Basal Ganglia Damage
Lateralized Deficits of Disgust Processing After Insula-Basal Ganglia Damage
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DOI：
10.3389/fpsyg.2020.01429
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发表时间：
2020-06-30
影响因子：
3.8
通讯作者：
Straube, Thomas
中科院分区：
文献类型：
--
作者：
Holtmann, Olga;Bruchmann, Maximilian;Straube, Thomas
越来越多的证据表明，岛叶皮层（IC）和基底神经节（BG）在厌恶的体验、表达和识别中发挥着重要作用。然而，人类病变的研究，探索这种结构-功能的联系，已经产生了相当不同的结果，在单一的情况下，单侧和双侧损害这些地区。比较组的方法是必要的，以阐明是否厌恶相关的赤字专门遵循损害的IC-BG系统，或者是否可能有一个差异半球的贡献厌恶处理。我们研究了情绪处理的全面的情绪测试电池在4例患者的左，右半球病变的IC-BG系统，以及在19名健康对照。虽然单一的测试没有提供明确的病人群体的分离，综合评分表明厌恶的选择性群体效应。重要的是，左病变患者表现出衰减的厌恶复合材料，而右病变患者表现出增加的厌恶复合材料，相比彼此和控制。这些发现提出了厌恶的左半球基础，可能是由于人类前脑自主信息的不对称表示。本研究首次提供了人类大脑中特定情绪半球侧化的行为证据，并有助于建立厌恶的神经生物学模型。
A growing body of evidence suggests a role of the insular cortex (IC) and the basal ganglia (BG) in the experience, expression, and recognition of disgust. However, human lesion research, probing this structure-function link, has yielded rather disparate findings in single cases of unilateral and bilateral damage to these areas. Comparative group approaches are needed to elucidate whether disgust-related deficits specifically follow damage to the IC-BG system, or whether there might be a differential hemispheric contribution to disgust processing. We examined emotional processing by means of a comprehensive emotional test battery in four patients with left- and four patients with right-hemispheric lesions to the IC-BG system as well as in 19 healthy controls. While single tests did not provide clear-cut separations of patient groups, composite scores indicated selective group effects for disgust. Importantly, left-lesioned patients presented attenuated disgust composites, while right-lesioned patients showed increased disgust composites, as compared to each other and controls. These findings propose a left-hemispheric basis of disgust, potentially due to asymmetrical representations of autonomic information in the human forebrain. The present study provides the first behavioral evidence of hemispheric lateralization of a specific emotion in the human brain, and contributes to neurobiological models of disgust.