A SCANNING AND TRANSMISSION ELECTRON MICROSCOPICAL STUDY OF THE MORPHOGENESIS OF HUMAN COLONIC VILLI
A SCANNING AND TRANSMISSION ELECTRON MICROSCOPICAL STUDY OF THE MORPHOGENESIS OF HUMAN COLONIC VILLI
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DOI：
10.1007/bf00305579
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
WILLIAMS, L
中科院分区：
文献类型：
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作者：
BELL, L;WILLIAMS, L
用光学显微镜、扫描和透射电子显微镜观察了人胎结肠绒毛发育过程中的形态发生过程。9周时，结肠是由假复层柱状上皮和间充质组成的简单管状结构。到10wk时，单个上皮细胞的伸长已经形成了多达8个纵脊。即使在脊状突起形成的同时，一些突起的底部也会形成间充质凹陷，从而形成纵向的粘膜皱折。到11.5wk时，它们已经以一种协和的方式折叠，形成了纵向的Z字形图案。从10.5开始，小腔在靠近其底部的上皮内发育。在这个阶段，它们与主管腔没有连续性。这些管腔延伸到主腔表面，多余的细胞脱落，导致之字形褶皱分裂成Braod初级绒毛。当在初级绒毛的假复层柱状上皮内发育的囊状结构扩大并延伸到管腔时，初级绒毛就会分裂。再加上间质的生长，这导致了小的次级绒毛和简单的柱状上皮。
The morphogenetic events that occur in the development of villi in human fetal colon were observed by light microscopy as well as scanning and transmission electron microscopy. At 9 wk, the colon is a simple tube composed of pseudostratified columnar epithelium and mesenchyme. By 10 wk, up to 8 longitudinal ridges have formed by an elongation of individual epithelial cells. Even as the ridges are forming, the bases of some of the ridges become indented with mesenchyme, thus forming longitudinal mucosal folds. By 11.5 wk, these have folded in a concertina fashion formimg a longitudinal zig-zag pattern. From 10.5, small lumina develop within the epithelium near to its base. At this stage, they are not in continuity with the main lumen. Extension of these lumina to the main luminal surface and exfoliation of redundant cells result in division of the zig-zag folds into braod primary villi. Division of the primary villi occurs when cyst-like structures which develop within the pseudostratified columnar epithelium of the primary villi enlarge and extend to the lumen. Together with upgrowth of mesenchyme this results in small secondary villi with simple columnar epithelium.