NORADRENERGIC NEURONS - MORPHINE-INHIBITION OF SPONTANEOUS ACTIVITY
NORADRENERGIC NEURONS - MORPHINE-INHIBITION OF SPONTANEOUS ACTIVITY
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DOI：
10.1016/0014-2999(74)90045-4
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发表时间：
1974-01-01
影响因子：
5
通讯作者：
AGHAJANIAN, GK
中科院分区：
文献类型：
--
作者：
KORF, J;BUNNEY, BS;AGHAJANIAN, GK
研究了硫酸吗啡对大鼠蓝斑区含去甲肾上腺素神经元自发放电率的影响。硫酸吗啡选择性地抑制蓝斑神经元的活性，但对中隔背核5 -羟色胺能神经元的放电率没有影响。吗啡拮抗剂纳洛酮阻断并逆转吗啡诱导的蓝斑细胞抑制。氯丙嗪的抗安非他明作用不同，它不能拮抗吗啡对NE细胞自发活性的抑制。纳洛酮不能阻断或逆转d-安非他明对去甲肾上腺素能神经元活性的抑制作用。一种有害的刺激（脚趾压力）会短暂地增加蓝斑中神经元的放电率。硫酸吗啡明显减轻了这种反应。这些发现表明吗啡可能通过减少蓝斑冲动流发挥至少部分的镇痛作用。然而，吗啡降低去甲肾上腺素能神经元活动的机制仍有待阐明。
The effect of morphine sulfate on the spontaneous firing rate of norepinephrine-containing neurons in the locus coeruleus was studied in rats. Morphine sulfate was found to selectively inhibit neuronal activity in the locus coeruleus but had no effect on the firing rate of serotonergic neurons in the dorsal raphe nucleus. Naloxone, a morphine antagonist, blocked and reversed the morphine-induced inhibition of locus coeruleus cells. Chlorpromazine, in contrast to its anti-amphetamine effects, did not antagonize the depression of spontaneous activity of the NE cells by morphine. Naloxone was ineffective in blocking or reversing d-amphetamine inhibition of noradrenergic neuron activity. A noxious stimulus (toe pressure) transiently increased the firing rate of neurons in the locus coeruleus. This response was markedly reduced by morphine sulfate.These findings suggest that morphine may exert at least part of this analgesic action through decreasing locus coeruleus impulse flow. However, the mechanism by which morphine decreases noradrenergic neuronal activity remains to be elucidated.