Data on the involvement of endothelin-1 (ET-1) in the dysregulation of retinal veins.
Data on the involvement of endothelin-1 (ET-1) in the dysregulation of retinal veins.
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DOI：
10.1016/j.dib.2018.09.070
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发表时间：
2018-12
期刊：
影响因子：
1.2
通讯作者：
Ikeda T
中科院分区：
文献类型：
--
作者：
Kida T;Flammer J;Oku H;Konieczka K;Morishita S;Horie T;Ikeda T
视网膜静脉阻塞（RVO）是一种常见的视网膜血管疾病；然而，RVO的发病机制仍不清楚。分支 RVO (BRVO) 通常发生在动静脉交叉处，以前认为患病的动脉机械压迫静脉。然而，据报道，在动脉交叉的眼睛中，视网膜静脉在动静脉交叉处深入动脉下方，并且静脉腔通常似乎被保留，即使在动静脉交叉处，如光学相干断层扫描所示。帕克斯等人。使用自适应光学成像发现没有动静脉接触的静脉切口。因此，我们研究了视网膜静脉失调的潜在作用。虽然视网膜静脉阻塞 (RVO) 的发病机制仍不清楚，但全身性高血压和内皮素-1 (ET-1) 水平升高是已知的危险因素 (Flammer 和 Konieczka, 2015)。我们关注自发性高血压大鼠（SHR）视网膜静脉的行为。然后，其中一根视网膜静脉变得异常收缩并几乎闭塞（图1），静脉注射ET-1后，SHR视网膜中的脉络膜视网膜血流量显着减少。此外，SHR视网膜对ET-A受体的免疫反应性高于对照（WKY；Wistar京都大鼠）视网膜（图2）。 SHR 视网膜中的 ET-A 受体和 HIF-1 蛋白水平也显着高于 WKY 视网膜（图 3）。我们观察了视网膜静脉的血管活性；视网膜静脉收缩（Kida et al., 2018）。这支持了这样的假设：ET-1可以收缩视网膜静脉，从而增加视网膜静脉压，并且ET-1甚至可能有助于RVO的发病机制。
Retinal vein occlusion (RVO) is a common vascular disease of the retina; however, the pathogenesis of RVO is still unclear. Branch RVO (BRVO) commonly occurs at the arteriovenous crossing and it was formerly believed that the diseased artery mechanically compresses the vein. However, it has been reported that the retinal vein runs deep beneath the artery at the arteriovenous crossing in eyes with an arterial overcrossing, and the venous lumen often appears to be preserved, even at the arteriovenous crossing, as shown by optical coherence tomography. Paques et al. found venous nicking without arteriovenous contact using adaptive optics imaging. Thus, we investigated the potential role of a dysregulation of the retinal vein. While the pathogenesis of retinal vein occlusion (RVO) is still unclear, systemic hypertension and increased level of endothelin-1 (ET-1) are known risk factors (Flammer and Konieczka, 2015). We focused on the behavior of retinal veins in spontaneous hypertensive rats (SHR). Then, one of the retinal veins became exceptionally constricted and was nearly occluded (Fig. 1), and the chorioretinal blood flow significantly decreased in the retinas of SHRs following the intravenous injection of ET-1. In addition, immunoreactivity to ET-A receptor was higher in SHR retinas than in control (WKY; Wistar Kyoto rat) retinas (Fig. 2). The protein levels of ET-A receptor and HIF-1 were also significantly higher in SHR retinas than in WKY retinas (Fig. 3). We observed vasoactivity of retinal veins; a retinal venous constriction (Kida et al., 2018). This supports the hypothesis that ET-1 can constrict retinal veins, thus increasing retinal venous pressure, and that ET-1 may even contribute to the pathogenesis of RVO.
DOI：
10.1186/s13167-015-0043-1
发表时间：
2015
期刊：
The EPMA journal
影响因子：
--
作者：
Flammer J;Konieczka K
通讯作者：
Konieczka K
影响因子：
8.1
作者：
Paques, Michel;Brolly, Aurelie;Girmens, Jean-Francois
通讯作者：
Girmens, Jean-Francois
影响因子：
3.4
作者：
Kida, Teruyo;Flammer, Josef;Ikeda, Tsunehiko
通讯作者：
Ikeda, Tsunehiko