Effects of heavy in utero cocaine exposure on adolescent caudate morphology
Effects of heavy in utero cocaine exposure on adolescent caudate morphology
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DOI：
10.1016/j.pediatrneurol.2007.06.012
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发表时间：
2007-10-01
影响因子：
3.8
通讯作者：
Gee, James C.
中科院分区：
文献类型：
--
作者：
Avants, Brian B.;Hurt, Hallam;Gee, James C.
我们通过高分辨率磁共振成像评估宫内可卡因和多药治疗暴露对青少年尾状核的影响。暴露于可卡因可能通过破坏多巴胺能系统中的神经个体发生、继发于胎儿低氧血症的效应或改变脑血管反应性而损害发育中的大脑。暴露于可卡因也可能导致新生儿尾状核病变。然而，宫内可卡因暴露的长期或潜在影响很少被发现。我们使用T-1加权磁共振成像来量化匹配的对照组和暴露组的尾状核形态。文献表明，青少年在子宫内接触可卡因的后果可能是微妙的，或被其他变量掩盖。我们的比较重点是将对照组与高暴露受试者（报告妊娠期间使用可卡因的中位数为117天的母亲; 82%在足月时可卡因使用检测呈阳性）进行对比。我们使用先进的图像配准和分割工具来量化左右尾状核形态。我们的研究结果表明，对照组的尾状核明显大于受试者（P < 0.0025），这意味着可卡因对多巴胺能系统的抑制作用。右侧（P < 0.025）和左侧（P < 0.035）尾状核，独立研究，显示出相同的显着趋势。使用排列测试和错误发现率来评估显著性。(c)2007年，Elsevier Inc. All rights reserved.
We assess the effects of in utero cocaine and polysuhstance exposure on the adolescent caudate nucleus through high-resolution magnetic resonance imaging. Cocaine exposure may compromise the developing brain through disruption of neural ontogeny in dopaminergic systems, effects secondary to fetal hypoxemia, or altered cerebrovascular reactivity. Cocaine exposure may also lead to neonatal lesions in the caudate. However, long-term or latent effects of intrauterine cocaine exposure are rarely found. We use T-1-weighted magnetic resonance imaging to quantify caudate nucleus morphology in matched control and exposed groups. The literature suggests that in utero cocaine exposure consequences in adolescents may be subtle, or masked by other variables. Our comparison focuses on contrasting the control group with high-exposure subjects (mothers who reported 2 median of 117 days of cocaine use during pregnancy; 82% tested positive for cocaine use at term). We use advanced image registration and segmentation tools to quantify left and right caudate morphology. Our results indicate that the caudate is significantly larger in controls versus subjects (P < 0.0025), implying cocaine exposure-related detriments to the dopaminergic system. The right (P < 0.025) and left (P < 0.035) caudate, studied independently, show the same significant trend. Permutation testing and the false discovery rate were used to assess significance. (c) 2007 by Elsevier Inc. All rights reserved.