Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro.
Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro.
复制标题
人类肿瘤合成肽与甲状旁腺激素在体内和体外的相似性。
DOI：
10.1126/science.3685994
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Schofield,TL
中科院分区：
文献类型：
--
作者：
Horiuchi,N;Caulfield,MP;Fisher,JE;Goldman,ME;McKee,RL;Reagan,JE;Levy,JJ;Nutt,RF;Rodan,SB;Schofield,TL
恶性肿瘤常伴发高钙血症，其机制之一是肿瘤分泌一种改变钙代谢的循环因子。最近确定了肿瘤分泌肽的结构，并发现其与甲状旁腺激素（PTH）部分同源。合成了该因子的氨基端1-34区，并进行了生物学评价。在体内，它产生高钙血症，作用于骨和肾，并刺激1，25-二羟维生素D3的形成。在体外，它与PTH受体相互作用，在某些系统中，比PTH更有效。这些研究支持了一个长期存在的关于恶性肿瘤相关高钙血症发病机制的假设。
One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The amino-terminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxy-vitamin D3formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.