Reproductive factors and risk of lung cancer in female textile workers in Shanghai, China.
Reproductive factors and risk of lung cancer in female textile workers in Shanghai, China.
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DOI：
10.1007/s10552-013-0208-y
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发表时间：
2013-07
影响因子：
2.3
通讯作者：
Thomas, David B.
中科院分区：
文献类型：
--
作者：
Gallagher, Lisa G.;Rosenblatt, Karin A.;Ray, Roberta M.;Li, Wenjin;Gao, Dao L.;Applebaum, Katie M.;Checkoway, Harvey;Thomas, David B.
激素因素可能在女性肺癌的发展中起作用。这项研究在一个大的女性队列中研究了肺癌与生殖因素之间的关系，其中大多数人从不吸烟（97%）。在中国上海，267,400名纺织女工参加了一项乳房自我检查试验，提供了1989-91年登记时的生殖史、人口统计学因素和吸烟情况。该队列随访至2000年7月肺癌发病率;确定了824例病例。使用考克斯比例风险模型计算与选定生殖因素相关的风险比（HR）和95%置信区间（CI），调整吸烟、年龄和相关产次。与经产女性相比，未生育女性的风险增加（HR= 1.33，95% CI 1.00-1.77）。在基线时已经过绝经期的妇女与同龄仍在绝经期的妇女相比，风险增加。手术绝经的妇女风险更高（HR=1.64，95%CI 0.96-2.79）（HR=1.35，95%CI 0.84-2.18），在基线时接受子宫切除术和双侧卵巢切除术的绝经后妇女中风险最高（HR=1.39，95% CI 0.96-2.00），尽管风险估计值无统计学显著性。这些结果支持了实验数据，证明了激素在肺癌发生中的生物学作用。
Hormonal factors may play a role in the development of lung cancer in women. This study examined the relationship between lung cancer and reproductive factors in a large cohort of women, most of whom never smoked (97%). A cohort of 267,400 female textile workers in Shanghai, China, enrolled in a trial of breast self-examination provided information on reproductive history, demographic factors and cigarette smoking at enrollment in 1989–91. The cohort was followed until July of 2000 for incidence of lung cancer; 824 cases were identified. Hazard ratios (HR) and 95% confidence intervals (CI) associated with selected reproductive factors were calculated using Cox proportional hazards modeling, adjusting for smoking, age, and also parity when relevant. Nulliparous women were at increased risk compared to parous women (HR= 1.33, 95% CI 1.00–1.77). Women who had gone through menopause at baseline were at increased risk compared to women of the same age who were still menstruating. Risk was higher in women with a surgical menopause (HR=1.64, 95%CI 0.96–2.79) than in those with a natural menopause (HR=1.35, 95% CI 0.84–2.18), and risk was highest in those postmenopausal women with a hysterectomy and bilateral oophorectomy at baseline (HR=1.39, 95% CI 0.96–2.00), although the risk estimates were not statistically significant. These results support experimental data that demonstrate a biological role for hormones in lung carcinogenesis.
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影响因子：
7.2
作者：
Parker WH;Broder MS;Chang E;Feskanich D;Farquhar C;Liu Z;Shoupe D;Berek JS;Hankinson S;Manson JE
通讯作者：
Manson JE
影响因子：
5
作者：
Lim, Wei-Yen;Chen, Ying;Seow, Adeline
通讯作者：
Seow, Adeline
中国上海女性肺鳞癌和腺癌与月经史的关系研究
影响因子：
5.3
作者：
Liao, ML;Wang, JH;You, WQ
通讯作者：
You, WQ
影响因子：
10.3
作者：
Chlebowski, Rowan T.;Anderson, Garnet L.;Stefanick, Marcia L.
通讯作者：
Stefanick, Marcia L.
影响因子：
10.3
作者：
Astrakianakis, George;Seixas, Noah S.;Checkoway, Harvey
通讯作者：
Checkoway, Harvey