INTERMEDIATE TROPHOBLAST - A DISTINCTIVE FORM OF TROPHOBLAST WITH SPECIFIC MORPHOLOGICAL, BIOCHEMICAL AND FUNCTIONAL FEATURES
INTERMEDIATE TROPHOBLAST - A DISTINCTIVE FORM OF TROPHOBLAST WITH SPECIFIC MORPHOLOGICAL, BIOCHEMICAL AND FUNCTIONAL FEATURES
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DOI：
10.1016/s0143-4004(84)80015-6
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发表时间：
1984-01-01
期刊：
影响因子：
3.8
通讯作者：
CHEN, HC
中科院分区：
文献类型：
--
作者：
KURMAN, RJ;MAIN, CS;CHEN, HC
使用针对人绒毛膜促性腺激素β-独特的羧基末端多肽的抗体对胎盘组织从12天到足月的形态和免疫组织化学分析。亚基，人胎盘催乳素(HPL)和妊娠特异性β。1-糖蛋白表明存在一种具有鲜明特征的中间形态的滋养细胞。该细胞形态多样，位于绒毛上、滋养层柱、基底板和滋养层壳内。虽然这3种胎盘蛋白都定位于该细胞，但主要的激素是HPL，它可以作为免疫细胞化学标记。这种细胞的主要功能之一是着床和建立子宫胎盘循环，因为它广泛地侵入胎盘部位的螺旋动脉。这种独特的滋养层细胞应称为中间滋养层细胞。
Morphological and immunohistochemical analysis of placental tissue from 12 days to term using antibodies directed against the unique carboxyl terminal peptide of human chorionic gonadotropin .beta. subunit, human placental lactogen (hPL) and pregnancy-specific .beta. 1-glycoprotein reveals that an intermediate form of trophoblast with distinctive features exists. This cell has a diverse morphological expression and is located overlying chorionic villi, in the trophoblastic columns, basal plate and the trophoblastic shell. Although all 3 placental proteins are localized in this cell, the predominant hormone is hPL, which can serve as an immunocytochemical marker. One of the primary functions of this cell is in implantation and in the establishment of the uteroplacental circulation since it extensively invades the spiral arteries at the placental site. This distinctive form of trophoblast should be termed intermediate trophoblast.