Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
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DOI：
10.1038/npp.2009.184
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发表时间：
2010-02-01
影响因子：
7.6
通讯作者：
McGuire, Philip K.
中科院分区：
文献类型：
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作者：
Bhattacharyya, Sagnik;Morrison, Paul D.;McGuire, Philip K.
Delta-9-tetrahydrocannabinol（Delta-9-THC）和Cannabidiol（CBD）是大麻植物的两种主要成分，具有明显的症状和行为效应。我们在健康志愿者中使用功能性磁共振成像（fMRI）来检查Delta-9-THC和CBD是否对局部脑功能有相反的影响。然后，我们评估了CBD预处理是否可以预防Delta-9-THC诱导的急性精神病症状。15名早期接触大麻最少的健康男性在进行言语记忆任务、反应抑制任务、感觉处理任务和观看恐惧面孔时进行扫描。受试者进行了三次扫描，每次扫描前口服Delta-9-THC、CBD或安慰剂。使用fMRI测量BOLD反应。在第二个实验中，6名健康志愿者在安慰剂或CBD预处理后两次静脉注射Delta-9-THC，以检查CBD是否可以阻断Delta-9-THC诱导的精神病症状。与安慰剂相比，Delta-9-THC和CBD在言语回忆时对纹状体的激活有相反的影响，在反应抑制任务中对海马体的激活有相反的影响，在受试者看到恐惧面孔时对杏仁核的激活有相反的影响，在受试者听演讲时对上级颞叶皮层的激活有相反的影响，在视觉处理过程中对枕叶皮层的激活有相反的影响。在第二个实验中，CBD预处理防止了Delta-9-tetrahydrocannabinol对精神病症状的急性诱导。Delta-9-THC和CBD可能对局部脑功能产生相反的影响，这可能是它们不同的症状和行为影响的基础，以及CBD阻断Delta-9-THC的精神作用的能力。Neuropsychopharmacology（2010）35，764-774; doi：10.1038/npp.2009.184; 2009年11月18日在线发表
Delta-9-tetrahydrocannabinol (Delta-9-THC) and Cannabidiol (CBD), the two main ingredients of the Cannabis sativa plant have distinct symptomatic and behavioral effects. We used functional magnetic resonance imaging (fMRI) in healthy volunteers to examine whether Delta-9-THC and CBD had opposite effects on regional brain function. We then assessed whether pretreatment with CBD can prevent the acute psychotic symptoms induced by Delta-9-THC. Fifteen healthy men with minimal earlier exposure to cannabis were scanned while performing a verbal memory task, a response inhibition task, a sensory processing task, and when viewing fearful faces. Subjects were scanned on three occasions, each preceded by oral administration of Delta-9-THC, CBD, or placebo. BOLD responses were measured using fMRI. In a second experiment, six healthy volunteers were administered Delta-9-THC intravenously on two occasions, after placebo or CBD pretreatment to examine whether CBD could block the psychotic symptoms induced by Delta-9-THC. Delta-9-THC and CBD had opposite effects on activation relative to placebo in the striatum during verbal recall, in the hippocampus during the response inhibition task, in the amygdala when subjects viewed fearful faces, in the superior temporal cortex when subjects listened to speech, and in the occipital cortex during visual processing. In the second experiment, pretreatment with CBD prevented the acute induction of psychotic symptoms by Delta-9-tetrahydrocannabinol. Delta-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Delta-9-THC. Neuropsychopharmacology (2010) 35, 764-774; doi:10.1038/npp.2009.184; published online 18 November 2009