Early onset of reproductive function in normal female mice treated with leptin
Early onset of reproductive function in normal female mice treated with leptin
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DOI：
10.1126/science.275.5296.88
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发表时间：
1997-01-03
期刊：
影响因子：
56.9
通讯作者：
Lim, ME
中科院分区：
文献类型：
--
作者：
Chehab, FF;Mounzih, K;Lim, ME
许多研究已经揭示了营养状况、肥胖和生殖成熟之间的关联。研究了瘦素（一种由脂肪组织分泌的激素）在生殖功能发生中的作用。正常青春期前的雌性小鼠注射瘦素的生长速度比对照组慢，这是由于激素的瘦身效果，但它们比对照组早9天繁殖，并显示出生殖道的早期成熟。这些结果表明，瘦素作为一个信号触发青春期，从而支持的假设，脂肪积累促进生殖道的成熟。
Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract.