CONFORMATIONS IN POLYSACCHARIDES AND COMPLEX CARBOHYDRATES
CONFORMATIONS IN POLYSACCHARIDES AND COMPLEX CARBOHYDRATES
复制标题
DOI：
10.1007/bf02703990
复制
发表时间：
1985-01-01
影响因子：
2.9
通讯作者：
ATKINS, E
中科院分区：
文献类型：
--
作者：
ATKINS, E
综述重点关注多糖和复杂碳水化合物的结构分子生物学，使用从水生植物、动物、细菌和昆虫获得的例子。多糖中缩合键的类型和顺序决定其构象、灵活性和相互作用。广泛多样的几何形状由组成糖单元本身、侧附属物和装饰所覆盖。 聚合后化学和结构修饰 来自定向样品和计算机建模的 X 射线衍射信息已用于分析分子构象和几何形状 一般来说，化学上较简单的多糖的糖苷键几何形状和构象之间的关系是可以理解的 对于更复杂的碳水化合物，单独使用衍射方法很难建立独特的解决方案 在混合蛋白质碳水化合物中 昆虫角质层中的糖蛋白防冻剂和蛋白质-多糖纤维复合材料等系统，可以有效地探索和检查结构、形态和相互作用方面的新特征。
A review is presented focussing attention on the structural molecular biology of polysaccharides and complex carbohydrates, using examples obtained from terraqueous plants, animals, bacteria and insects The type and sequence of the condensation linkages in polysaccharides dominate their conformation, flexibility and interactions The extensive variety of geometries is overlaid by the constituent saccharide units themselves, decoration by side appendages and post-polymerisation chemical and structural modification X-ray diffraction information from oriented samples and computerised modelling has been used to analyse molecular conformation and geometry In general the relationship between glycosidic linkage geometry and conformation for the chemically simpler polysaccharides is understood In the case of more complex carbohydrates, unique solutions using diffraction methods alone are harder to establish In mixed protein carbohydrate systems, such as the glycoprotein antifreezes and protein-polysaccharide fibrous composites in insect cuticle, novel features in structure, morphology and interactions can usefully be explored and examined.