Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp FKI-1938
Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp FKI-1938
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DOI：
10.1038/ja.2008.73
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发表时间：
2008-09-01
影响因子：
3.3
通讯作者：
Omura, Satoshi
中科院分区：
文献类型：
--
作者：
Fukuda, Takashi;Hasegawa, Yoko;Omura, Satoshi
采用溶剂萃取、硅胶柱层析和高效液相色谱法从青霉FKI-1938发酵液中分离到两种新的芳香生物碱，分别为黄酰胺A和B。通过核磁共振和氨基酸分析对其结构进行了鉴定。黄酰胺A和B对白色念珠菌的活性有中等增强作用。
Two new aromatic alkaloids, designated citrinamides A and B, were isolated from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analysis, including NMR and amino acid analysis. Citrinamides A and B showed moderate potentiation of miconazole activity against Candida albicans.