Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration.
Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration.
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异丙酚对大鼠伤害性反应以及脑电图和全身动脉压信号功率谱的影响：与血浆浓度的相关性。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
S. Chan
中科院分区：
文献类型：
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作者：
C. H. Yang;M. Shyr;T. B. Kuo;P. P. Tan;S. Chan
应用脑电(EEG)和全身动脉压信号的同步频谱分析方法，对异丙酚静脉麻醉大鼠的意识状态和心血管功能进行监测，并探讨其与丙泊酚血药浓度的相关性。我们的结果支持丙泊酚麻醉存在“阈值”血药浓度(1.7-1.8微克/毫升)的假设。我们进一步表明，这一阈值水平可以通过两种静脉注射达到。团注和持续输注，尽管药代动力学特征以及脑电和血流动力学的相关性可能不同。连续的、在线的脑电信号功率谱分析显示，脑电波的theta和Delta频段功率密度以及均方根值的降低程度与麻醉程度平行。只有在脑电爆发抑制的同时，α和β分量才会显著抑制。在亚麻药剂量下，静脉注射。输注异丙酚优先增加了theta和Delta频段的功率密度，这表明将镇静作为异丙酚的非催眠治疗应用是有效的。我们还发现，只有麻醉剂量的异丙酚才会产生明显的心血管抑制。全身动脉压力信号的功率谱分析表明，伴随着代表外周血管阻力和压力感受器反射反应的频谱参数的进行性降低。
We applied simultaneous spectral analysis of electroencephalographic (EEG) and systemic arterial pressure signals in Sprague-Dawley rats to monitor the status of consciousness and cardiovascular functions during intravenous anesthesia with propofol and to assess their correlations with plasma propofol concentration. Our results support the hypothesis that a 'threshold' plasma concentration (1.7-1.8 micrograms/ml) exists for propofol anesthesia. This threshold level, we further showed, may be attained by both i.v. bolus injection and continuous infusion, although the pharmacokinetic profiles, as well as EEG and hemodynamic correlates, may be different. Continuous, on-line power spectral analysis of EEG signals revealed that the degree of reduction in the power density of the theta and delta bands and root mean square value paralleled the level of anesthesia. Significant suppression of both alpha and beta components occurred only concomitant with EEG burst suppression. At the subanesthetic dose, i.v. infusion of propofol increased preferentially the power density of the theta and delta bands, suggesting the validity of including sedation as a nonhypnotic therapeutic application of propofol. We also found that appreciable cardiovascular suppression took place only upon anesthetic doses of propofol. Power spectral analysis of systemic arterial pressure signals indicated that this was accompanied by a progressive depression of spectral parameters that signify peripheral vascular resistance and baroreceptor reflex response.