CELLULAR ONCOGENES AND MULTISTEP CARCINOGENESIS
CELLULAR ONCOGENES AND MULTISTEP CARCINOGENESIS
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DOI：
10.1126/science.6356358
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
WEINBERG, RA
中科院分区：
文献类型：
--
作者：
LAND, H;PARADA, LF;WEINBERG, RA
到目前为止，通过对逆转录病毒的研究和基因转移的使用，已经发现了24个细胞原癌基因。它们在结构和功能上形成了一个不同的群体。至少有五种不同的机制负责它们向活性癌基因的转化。最近的工作提供了实验策略，通过这些策略，许多这些癌基因以及DNA肿瘤病毒的癌基因可以被归入功能类别。这些过程可能会导致定义一些共同的途径，通过这些途径，各种癌基因可以转化细胞。
Two dozen cellular proto-oncogenes have been discovered to date through the study of retroviruses and the use of gene transfer. They form a structurally and functionally heterogeneous group. At least five distinct mechanisms are responsible for their conversion to active oncogenes. Recent work provides experimental strategies by which many of these oncogenes, as well as oncogenes of DNA tumor viruses, may be placed into functional categories. These procedures may lead to definition of a small number of common pathways through which the various oncogenes act to transform cells.