POSSIBLE INVOLVEMENT OF CENTRAL ADRENALIN NEURONS IN VASOMOTOR AND RESPIRATORY CONTROL - STUDIES WITH CLONIDINE AND ITS INTERACTIONS WITH PIPEROXANE AND YOHIMBINE
POSSIBLE INVOLVEMENT OF CENTRAL ADRENALIN NEURONS IN VASOMOTOR AND RESPIRATORY CONTROL - STUDIES WITH CLONIDINE AND ITS INTERACTIONS WITH PIPEROXANE AND YOHIMBINE
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DOI：
10.1016/0014-2999(74)90116-2
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发表时间：
1974-01-01
影响因子：
5
通讯作者：
GOLDSTEIN, M
中科院分区：
文献类型：
--
作者：
BOLME, P;CORRODI, H;GOLDSTEIN, M
在氯醛中毒大鼠中，三嗪（20 mg/kg）和育亨宾（1 mg/kg）可阻断可乐定（5 μg/kg）的催喘和呼吸作用。这些剂量的哌珀生和育亨宾没有阻断或减少可乐定诱导的屈肌反射活动的增加，这取决于去甲肾上腺素（NA）受体活性。高剂量的piperoxane（20毫克/公斤）增加脑NA营业额，和低剂量（5毫克/公斤）选择性地增加皮质NA营业额;育亨宾后发生类似的结果。目前的结果可以解释的基础上，低剂量的可乐定选择性地刺激肾上腺素（A）受体介导可乐定的扩张和呼吸作用。因此，肾上腺素神经元可能参与血管扩张和呼吸控制。
Piperoxane (20 mg/kg) and yohimbine (1 mg/kg) blocked the hypotensive and respiratory actions of clonidine (5 μg/kg) in chloralosed rats. These doses of piperoxane and yohimbine did not block or reduce clonidine-induced increases in flexor reflex activity, which is dependent on noradrenaline (NA) receptor activity. High doses of piperoxane (20 mg/kg) increased brain NA turnover, and low doses (5 mg/kg) selectively increased cortical NA turnover; similar results occurred after yohimbine. The present results can be explained on the basis of low doses of clonidine selectively stimulating adrenaline (A) receptors which mediate the hypotensive and respiratory actions of clonidine. Adrenaline neurons may, thus, be involved in vasomotor and respiratory control.