Model of recovery of locomotor ability after sensorimotor cortex injury in rats
Model of recovery of locomotor ability after sensorimotor cortex injury in rats
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DOI：
10.1093/ilar.44.2.125
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发表时间：
2003-01-01
期刊：
影响因子：
2.5
通讯作者：
Goldstein, LB
中科院分区：
文献类型：
--
作者：
Goldstein, LB
脑损伤后运动恢复的动物模型为理解人类中风后恢复的基本神经生物学过程提供了工具。测量大鼠穿越狭窄高架梁的能力已被证明是一种特别有用的运动功能测试。随着时间的推移，这种行为的重复测量提供了一种简单的方法，用于量化大鼠感觉运动皮层损伤后运动恢复的速率和程度，并构成了研究其机制和可能的治疗策略的工具。该模型已被证明在预测药物对人类中风后恢复的影响方面特别有用。
Animal models of locomotor recovery after brain injury provide tools for understanding the basic neurobiological processes that may underlie recovery after stroke in humans. Measurement of the ability of rats to traverse a narrow elevated beam has proven to be a particularly useful test of locomotor function. Repeated measurement of this behavior over time provides a simple method for quantifying the rate and degree of a rat's locomotor recovery after sensorimotor cortex injury and constitutes a tool for studying its mechanisms and possible treatment strategies. The model has proven particularly useful in predicting the effects of drugs on poststroke recovery in humans.