Pathological studies on postvaccinal reactions of Rift Valley fever in goats.
Pathological studies on postvaccinal reactions of Rift Valley fever in goats.
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DOI：
10.1186/1743-422x-6-94
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发表时间：
2009-07-06
期刊：
影响因子：
4.8
通讯作者：
Kamal SA
中科院分区：
文献类型：
--
作者：
Kamal SA
以山羊为实验动物，对裂谷热减毒活疫苗（史密斯本株）进行评价。结果表明，这种疫苗会引起肝脏严重的有害病理变化，尤其是儿童，并导致孕妇流产。病毒在肝细胞内繁殖，形成核内包涵体，E.M.也发现了这一点。使用免疫荧光技术在肝细胞、胆囊、血管内皮层、白细胞、肾脏和心脏中检测到病毒抗原。可以得出的结论是，使用 RVF（史密斯伯恩株）减毒活疫苗对家畜进行免疫在埃及并不安全，因为埃及被视为流行区。
RVF live attenuated vaccine (Smithburn strain) was evaluated by using goats as experimental animal. The results indicate that this vaccine cause severe deleterious pathological changes in liver especially in kids and causing abortion in pregnant does. The virus was seen to be propagated inside hepatic cells forming intranuclear inclusions which was also seen by E.M. Viral antigens were detected in hepatic cells, gall bladder, endothelial lining of blood vessels, leukocytes, kidneys and heart by using immunoflourescent technique. It could be concluded that the use of live attenuated vaccine of RVF (Smithburn strain) for immunization of live stock is not safe in Egypt as it considered an endemic area.