Dysfunction of ventral striatal reward prediction in schizophrenia
Dysfunction of ventral striatal reward prediction in schizophrenia
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DOI：
10.1016/j.neuroimage.2005.07.051
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发表时间：
2006-01-15
期刊：
影响因子：
5.7
通讯作者：
Heinz, A
中科院分区：
文献类型：
--
作者：
Juckel, G;Schlagenhauf, F;Heinz, A
背景阴性症状可能与精神分裂症患者大脑奖励系统功能障碍有关。我们使用功能性磁共振成像（fMRI）来评估未服药的精神分裂症患者在呈现奖励指示和损失指示刺激时腹侧纹状体的BOLD反应。总共有10名精神分裂症患者（7名从未服药，3名至少2年未服药）和10名年龄匹配的健康男性志愿者参加了一项奖励性金钱延迟任务，在视觉线索预测，快速反应，随后的目标刺激将导致要么在金钱上的收益或损失，或将没有consequence.Results：与健康对照组相比，未服药的精神分裂症患者表现出减少腹侧纹状体激活过程中的奖励指示线索的介绍。左腹侧纹状体的激活减少与阴性症状的严重程度呈负相关（和趋势阳性）symptoms.Discussion：大脑奖励系统的中心区域之一腹侧纹状体的激活减少与无药物治疗的精神分裂症患者阴性症状的严重程度相关。在未经药物治疗的精神分裂症患者中，高纹状体多巴胺周转率可能会增加奖励系统中的“噪音”，从而干扰神经元对阶段性多巴胺释放的奖励预测线索的处理。反过来，这可能会导致负面症状，如快感缺乏，冷漠，失去动力和动机。(c)2005年爱思唯尔公司All rights reserved.
Background. Negative symptoms may be associated with dysfunction of the brain reward system in schizophrenia. We used functional magnetic resonance imaging (fMRI) to assess the BOLD response in the ventral striatum of unmedicated schizophrenics during presentation of reward-indicating and loss-indicating stimuli.Methods: A total of 10 schizophrenic men (7 never medicated, 3 unmedicated for at least 2 years) and 10 age-matched healthy male volunteers participated in an incentive monetary delay task, in which visual cues predicted that a rapid response to a subsequent target stimulus would result either in monetary gain or loss or would have no consequence.Results: Compared to healthy controls, unmedicated schizophrenics showed reduced ventral striatal activation during the presentation of reward-indicating cues. Decreased activation of the left ventral striatum was inversely correlated with the severity of negative (and trendwise positive) symptoms.Discussion: Reduced activation in one of the central areas of the brain reward system, the ventral striatum, was correlated with the severity of negative symptoms in medication-free schizophrenics. In unmedicated schizophrenic patients, a high striatal dopamine turnover may increase the "noise" in the reward system, thus interfering with the neuronal processing of reward-predicting cues by phasic dopamine release. This, in turn, may contribute to negative symptoms as such as anhedonia, apathy, and loss of drive and motivation. (c) 2005 Elsevier Inc. All rights reserved.