Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults
Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults
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DOI：
10.1016/j.vaccine.2005.01.080
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发表时间：
2005-05-09
期刊：
影响因子：
5.5
通讯作者：
Bleackley, RC
中科院分区：
文献类型：
--
作者：
McElhaney, JE;Hooton, JW;Bleackley, RC
这项研究比较了标准单剂量流感疫苗（SD）和初次接种16周后再次接种加强剂量流感疫苗（BD）的免疫反应。虽然接种疫苗后的血清保护率相似，但与BD组相比，SD组的t细胞反应得到了更理想的刺激。SD导致离体白介素-10 （IL-10）水平下降10倍以上（P < 0.0001），干扰素- γ (ifn - γ)与IL-10比值相应显著升高。虽然BD对IL-10的产生没有进一步的影响，但BD组的ifn - γ:IL-10比值下降（P < 0.001， A/H3N2和B株）。仅在SD组，ifn - γ:IL-10比值与血清抗体滴度（R = 0.37 ~ 0.50, P < 0.01）和体外颗粒酶B （Grz B）水平（R = 0.50 ~ 0.65, P < 0.01）显著相关
This study compared the immune response to the standard single-dose (SD) of influenza vaccine to a booster dose (BD) re-vaccination given 16 weeks after the initial dose. While seroprotection rates following vaccination were similar, T-cell responses were more optimally stimulated in the SD versus the BD group. SD lead to a greater than 10-fold decline in ex vivo interleukin-10 (IL-10) levels (P < .0001) and a corresponding significant increase in the interferon-gamma (IFN-gamma) to IL-10 ratio. Although BD had no further effect on IL-10 production, the IFN-gamma:IL-10 ratio declined in the BD group (P < .001, A/H3N2 and B strains). In the SD group only, IFN-gamma:IL-10 ratios significantly correlated with serum antibody titers (R = .37-.50, P < .01) and ex vivo granzyme B (Grz B) levels (R = .50-.65, P