Graphene nanopore devices for DNA sensing.
Graphene nanopore devices for DNA sensing.
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DOI：
10.1007/978-1-61779-773-6_12
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发表时间：
2012
影响因子：
--
通讯作者：
C. Merchant;M. Drndić
中科院分区：
文献类型：
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作者：
C. Merchant;M. Drndić
我们在此描述了一种通过石墨烯膜中创建的纳米孔检测单个 DNA 分子易位的方法。该器件由 1-5 nm 厚的石墨烯膜组成，具有电子束雕刻的直径为 5 至 10 nm 的纳米孔。由于石墨烯膜的薄特性和降低的电阻，我们观察到比传统固态纳米孔更大的阻塞电流。我们还展示了如何通过在石墨烯表面上原子层沉积几纳米的二氧化钛来降低离子电流噪声水平。与传统的绝缘固态纳米孔材料不同，石墨烯是一种优异的电导体，它的使用为未来新型纳米孔器件打开了大门，其中电子传感和控制直接在孔隙上进行。
We describe here a method for detecting the translocation of individual DNA molecules through nanopores created in graphene membranes. The devices consist of 1–5-nm thick graphene membranes with electron-beam sculpted nanopores from 5 to 10 nm in diameter. Due to the thin nature of the graphene membranes, and the reduced electrical resistance, we observe larger blocked currents than for traditional solid-state nanopores. We also show how ionic current noise levels can be reduced with the atomic-layer deposition of a few nanometers of titanium dioxide over the graphene surface. Unlike traditional solid-state nanopore materials that are insulating, graphene is an excellent electrical conductor, and its use opens the door to a new future class of nanopore devices in which electronic sensing and control is performed directly at the pore.