Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet
Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet
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DOI：
10.1002/mnfr.200900026
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发表时间：
2009-11-01
影响因子：
5.2
通讯作者：
Howard, Luke
中科院分区：
文献类型：
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作者：
Prior, Ronald L.;Wu, Xianli;Howard, Luke
雄性C57 BL/6小鼠接受含10% kcal脂肪的饲料或高脂肪饲料[45%（HF 45）或60%（HF 60）kcal脂肪]。饮食制备有或没有冻干粉（10%）从整个蓝莓（BB），草莓（SB），康科德葡萄或黑树莓。在第二项研究中，将来自SB或BB的纯化花青素（ACN）添加到喂食HF 60饮食的处理的饮用水中。在研究1中，通过饲喂HF 45饮食增加血清甘油三酯，但当HF 45饮食中包含黑树莓或BB时，血清甘油三酯进一步升高。在喂食HF 45饲料的小鼠中，肝脏总脂质和甘油三酯增加，并且与HF 45对照组相比，在HF 45饲料中包含任何浆果粉末都不会改变浓度。在第二项研究中，喂食HF 60饮食加上从水中的BB纯化的ACN的小鼠的体重增加和体脂低于喂食HF 60的小鼠。血清胆固醇和甘油三酯水平与HF 60饮食升高，并降低到控制水平时，从SB或BB的ACN包括在饮用水中。血清瘦素水平持续下降，以控制低脂肪水平的那些ACN治疗，其中体脂的措施减少。通过饮用水给予BB和草莓纯化的ACN可预防小鼠血脂异常和肥胖症的发生，但喂食含有全浆果或紫玉米（PC）ACN的饮食并不能改变肥胖症的发生。
Male C57BL/6 mice received diets with either 10% of kcal from fat, or a high fat diet [45% (HF45) or 60% (HF60) kcal from fat]. Diets were prepared with or without freeze-dried powders (10%) from whole blueberries (BB), strawberries (SB), Concord grape or black raspberry. In the 2nd study, purified anthocyanins (ACNs) from SB or BB were added to the drinking water of the treatments fed the HF60 diet. In Study 1, serum triglycerides were increased by feeding the HF45 diet but were elevated further when black raspberry or BB was included in the HF45 diet. Liver total lipids and triglycerides were increased in mice fed HF45 diet and inclusion of any of the berry powders in the HF45 diet did not alter concentrations compared to HF45 controls. In the 2nd study, mice fed the HF60 diet plus purified ACNs from BB in the water had lower body weight gains and body fat than the HF60 fed. Serum cholesterol and triglyceride levels were elevated with the HF60 diet and decreased to control levels when ACNs from either SB or BB were included in the drinking water. Serum leptin levels were consistently decreased to control low fat levels in those ACN treatments in which measures of body fat were decreased. Administering purified ACNs from BB and strawberry via drinking water prevented the development of dyslipidemia and obesity in mice, but feeding diets containing whole berries or purple corn (PC) ACNs did not alter the development of obesity.