Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction
Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction
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DOI：
10.1161/01.cir.94.12.3318
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发表时间：
1996-12-15
期刊：
影响因子：
37.8
通讯作者：
Judd, RM
中科院分区：
文献类型：
--
作者：
Kim, RJ;Chen, EL;Judd, RM
急性再灌注梗死的对比剂增强磁共振图像显示受损心肌的低增强和高增强区域。导致这些改变的增强模式的确切机制尚不清楚。本研究的目的是评估可能的机制，并与改变增强模式心肌灌注和viability.Methods和结果13只兔子进行了原位冠状动脉闭塞和再灌注，然后隔离灌注心脏停搏液。在灌注液Gd-DTPA浓度阶跃变化期间连续采集T1加权自旋回波图像。用放射性微球测定局部血流量。Gd-DTPA洗脱时间常数与对照组相比有显著性差异（洗脱时间常数分别为0.8 ± 0.1，2.1 ± 0.2，16.3 ± 2.4min，P
Background Contrast medium-enhanced magnetic resonance images of acute, reperfused infarcts have shown hypoenhanced and hyperenhanced regions in areas of injured myocardium. The precise mechanisms that lead to these altered enhancement patterns are unknown. This study was designed to evaluate possible mechanisms and to relate altered enhancement patterns to myocardial perfusion and viability.Methods and Results Thirteen rabbits underwent in situ coronary artery occlusion and reperfusion followed by isolated perfusion with cardioplegic solution. T1-weighted spin-echo images were acquired continuously during step changes in perfusate Gd-DTPA concentration. Regional blood flow was also measured by use of radioactive microspheres in all rabbits. There were marked differences in Gd-DTPA wash-in and washout time constants (wash-in, 0.8+/-0.1, 2.1+/-0.2, and 16.3+/-2.4 minutes, P