Elevated Fibroblast Growth Factor 23 Levels Are Associated With Greater Diastolic Dysfunction in ESRD.
Elevated Fibroblast Growth Factor 23 Levels Are Associated With Greater Diastolic Dysfunction in ESRD.
复制标题
成纤维细胞生长因子 23 水平升高与 ESRD 中更大的舒张功能障碍相关。
DOI：
10.1016/j.ekir.2019.07.022
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发表时间：
2019
影响因子：
6
通讯作者：
Nguyen,Kim-Lien
中科院分区：
文献类型：
--
作者：
Sharma,Shilpa;Hanudel,MarkR;Ix,JoachimH;Salusky,IsidroB;Ganz,Tomas;Nguyen,Kim-Lien
研究队列的基线特征如表1所示，按完整（i）FGF 23的四分位数分层。47名参与者中有70%是男性，62%的左心室射血分数（EF）保持不变。平均（±SD）年龄为61（±20）岁，平均磷酸盐为5.0（±1.4）mg/dl;平均LVEF为51（±13）%，平均左心房容积为58（±27）ml，平均三尖瓣速度为2.6（±0.5）m/sec，平均E（二尖瓣早期充盈速度）/A（二尖瓣晚期充盈速度）比值为1.4（±0.5）。共有94%（44/47）的患者有LV舒张功能障碍，53%（25/47）的患者有LV肥大（LVH）。
ResultsBaseline characteristics of the study cohort are shown in Table 1, stratified by quartiles of intact (i) FGF23. Seventy percent of the 47 participants were men, and 62% had preserved LV ejection fraction (EF). The mean (±SD) age was 61 (±20) years, mean phosphate was 5.0 (±1.4) mg/dl; mean LVEF was 51 (±13)%, mean left atrial volume was 58 (±27) ml, mean tricuspid velocity was 2.6 (±0.5) m/sec, and the mean E (transmitral early filling velocity)/A (transmitral late filling velocity) ratio was 1.4 (±0.5). A total of 94%(44 of 47) of patients had LV diastolic dysfunction, and 53%(25 of 47) had LV hypertrophy (LVH).