Molecular machinery of signal transduction and cell cycle regulation in Plasmodium.
Molecular machinery of signal transduction and cell cycle regulation in Plasmodium.
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DOI：
10.1016/j.molbiopara.2009.01.003
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发表时间：
2009-05
影响因子：
1.5
通讯作者：
Garcia, Celia R. S.
中科院分区：
文献类型：
--
作者：
Koyama, Fernanda C.;Chakrabarti, Debopam;Garcia, Celia R. S.
对疟原虫细胞周期的调节尚不清楚。虽然恶性疟原虫基因组已经完全测序，但大约60%的预测蛋白质与其他真核生物的序列相似性很小，甚至没有相似性。这一特征损害了对参与细胞周期调控的重要蛋白质的识别。有几个悬而未决的问题涉及疟疾寄生虫的细胞周期进程，包括控制多个核分裂的机制，以及如何在其复杂生命周期的所有阶段管理细胞周期。寄主体内寄生虫种群的细胞周期同步性以及增殖的昼夜节律是一些疟原虫的显著特征，其分子基础仍有待阐明。在这篇综述中，我们讨论了在疟原虫和其他真核生物中，吲哚相关分子作为信号调节细胞周期的作用，我们还考虑了激酶在信号转导和它所引发的反应中的可能作用。
The regulation of the Plasmodium cell cycle is not understood. Although the Plasmodium falciparum genome is completely sequenced, about 60% of the predicted proteins share little or no sequence similarity with other eukaryotes. This feature impairs the identification of important proteins participating in the regulation of the cell cycle. There are several open questions that concern cell cycle progression in malaria parasites, including the mechanism by which multiple nuclear divisions is controlled and how the cell cycle is managed in all phases of their complex life cycle. Cell cycle synchrony of the parasite population within the host, as well as the circadian rhythm of proliferation, are striking features of some Plasmodium species, the molecular basis of which remains to be elucidated. In this review we discuss the role of indole-related molecules as signals that modulate the cell cycle in Plasmodium and other eukaryotes, and we also consider the possible role of kinases in the signal transduction and in the responses it triggers.
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影响因子：
1.5
作者：
Farias, SL;Gazarini, ML;Garcia, CRS
通讯作者：
Garcia, CRS
影响因子：
2.9
作者：
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通讯作者：
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4.8
作者：
Carucci, DJ;Witney, AA;Baker, DA
通讯作者：
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影响因子：
1.5
作者：
Chen, Yueqin;Jirage, Dayadevi;Waters, Norman C.
通讯作者：
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影响因子：
10.3
作者：
Beraldo, Flavlo H.;Mikoshiba, Katsuhiko;Garcia, Celia R. S.
通讯作者：
Garcia, Celia R. S.