Structural and functional brain changes in early- and mid-stage primary open-angle glaucoma using voxel-based morphometry and functional magnetic resonance imaging.
Structural and functional brain changes in early- and mid-stage primary open-angle glaucoma using voxel-based morphometry and functional magnetic resonance imaging.
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DOI：
10.1097/md.0000000000006139
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发表时间：
2017-03
期刊：
影响因子：
1.6
通讯作者：
Huang XH
中科院分区：
文献类型：
--
作者：
Jiang MM;Zhou Q;Liu XY;Shi CZ;Chen J;Huang XH
采用基于指数李代数配准的体素形态测量（VBM-DARTEL）和血氧水平依赖功能磁共振成像（BOLD-fMRI）研究原发性开角型青光眼（POAG）患者的脑结构和功能变化。13名诊断为POAG的患者和13名年龄和性别匹配的健康对照者参加了这项研究。对于每个参与者，在3.0特斯拉磁共振成像（MRI）扫描仪上获得高分辨率脑结构成像和血流成像。分析POAG与对照组之间的结构和功能变化。进行分析以确定在先前分析中获得的结构和功能变化与视网膜神经纤维层（RNFL）之间的相关性。POAG组患者中脑、左脑干、额回、小脑蚓部、左顶下小叶、尾状核、丘脑、楔前叶和Brodmann 7、18和46区的体积显著增加（P<0.001）。 右侧缘上回、额回、上级额回、左侧顶下小叶、左侧楔叶、左侧扣带回中部等脑区BOLD信号变化显著（P <0.001），这些脑区与RNFL有高度相关性。 POAG患者的大脑皮质结构和血流发生广泛而复杂的变化。（ClinicalTrials.gov编号：NCT 02570867）。
To investigate structural and functional brain changes in patients with primary open-angle glaucoma (POAG) by using voxel-based morphometry based on diffeomorphic anatomical registration through exponentiated Lie algebra (VBM-DARTEL) and blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI), respectively. Thirteen patients diagnosed with POAG and 13 age- and sex-matched healthy controls were enrolled in the study. For each participant, high-resolution structural brain imaging and blood flow imaging were acquired on a 3.0-Tesla magnetic resonance imaging (MRI) scanner. Structural and functional changes between the POAG and control groups were analyzed. An analysis was carried out to identify correlations between structural and functional changes acquired in the previous analysis and the retinal nerve fiber layer (RNFL). Patients in the POAG group showed a significant (P < 0.001) volume increase in the midbrain, left brainstem, frontal gyrus, cerebellar vermis, left inferior parietal lobule, caudate nucleus, thalamus, precuneus, and Brodmann areas 7, 18, and 46. Moreover, significant (P < 0.001) BOLD signal changes were observed in the right supramarginal gyrus, frontal gyrus, superior frontal gyrus, left inferior parietal lobule, left cuneus, and left midcingulate area; many of these regions had high correlations with the RNFL. Patients with POAG undergo widespread and complex changes in cortical brain structure and blood flow. (ClinicalTrials.gov number: NCT02570867).