The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial
The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial
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DOI：
10.1016/j.dsx.2018.03.013
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发表时间：
2018-07-01
影响因子：
10
通讯作者：
Sirdah, Mahmoud M.
中科院分区：
文献类型：
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作者：
Abd El-Aal, Ali;Abd El-Ghffar, Eman A.;Sirdah, Mahmoud M.
背景与目的：近年来，抗氧化维生素对2型糖尿病患者口服降糖治疗效果的影响越来越受到关注。这项单盲随机对照临床试验旨在研究补充维生素C和/或E对加沙地带巴勒斯坦2型糖尿病男性患者口服降糖治疗疗效的影响。方法：40例40 ~ 60岁的男性T2DM患者接受二甲双胍治疗，随机分为4组，每组在对照组的基础上每日口服1种补充剂，连续90天：安慰剂；维生素C;禁食一夜后，采集所有个体静脉血标本，分别放入K3-EDTA管和血清管中，测定研究开始时和补充维生素90天后的生化和血液学参数。结果：维生素C和/或E可改善空腹血糖（FBS）、HbA1c、血脂、胰岛素、胰岛素抵抗稳态模型评估（HOMA-IR）、还原型谷胱甘肽（GSH）；胰岛素敏感性定量检查指数（QISCI）与安慰剂组比较。结论：本研究为补充抗氧化维生素对T2DM的有益作用提供了额外的证据，它可以改善临床状况，减轻或预防糖尿病的发病机制和并发症，其次，血糖控制不良可能归因于内源性抗氧化剂下降和活性氧产生增加之间的不平衡，导致糖尿病背景下氧化介导的损伤。(C) 2018年印度糖尿病。Elsevier Ltd.出版。版权所有。
Background and aim: Recently, there has been an increasing interest in the influence of antioxidant vitamins on the efficacy of oral hypoglycemic therapy in type 2 diabetic patients (T2DM). This single-blinded randomized controlled clinical trial aimed to investigate the effect of vitamin C and/or E supplementation on the efficacy of oral hypoglycemic therapy in T2DM Palestinian male patients from the Gaza Strip.Methods: Forty T2DM male patients aged 40-60 years on metformin treatment were randomly divided into four groups, each group received an additional one of the following daily oral supplements for 90 days: placebo; vitamin C; vitamin E and vitamin C plus vitamin E. After overnight fasting, venous blood specimens were collected from all individuals into K3-EDTA tubes and serum tubes for measuring the biochemical and hematological parameters of the study at baseline and after 90 days of vitamins supplementation.Results: The results revealed that vitamin C and/or E improve fasting blood sugar (FBS), HbA1c, lipid profile, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), reduced glutathione (GSH); and Quantitative Insulin Sensitivity Check Index (QISCI) compared with diabetic patients group that received placebo.Conclusion: This study provided additional evidence on the beneficial effects of supplementing antioxidant vitamins in T2DM which could improve the clinical condition and attenuate or prevent diabetic pathogenesis and complications that, secondly to poor glycemic control, could attribute to the imbalance between the decline in the endogenous antioxidants and increasing production of the reactive oxygen species leading to the oxidant-mediated damage present in the diabetic context. (C) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.