Decline of cerebral glucose metabolism in frontotemporal dementia:: a longitudinal 18F-FDG-PET-study
Decline of cerebral glucose metabolism in frontotemporal dementia:: a longitudinal 18F-FDG-PET-study
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DOI：
10.1016/j.neurobiolaging.2005.11.002
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发表时间：
2007-01-01
影响因子：
4.2
通讯作者：
Kurz, A.
中科院分区：
文献类型：
--
作者：
Diehl-Schmid, J.;Grimmer, T.;Kurz, A.
目的：确定额颞叶痴呆（FTD，额叶变异型）脑葡萄糖代谢下降的进展模式。方法：22 名轻度 FTD 患者在基线和平均 19.5 个月后的随访时接受 18F-FDG 正电子发射断层扫描。使用 SPM-99 将患者扫描结果与 15 名年龄匹配的健康对照受试者的扫描结果进行逐个体素的比较。结果：与基线时的健康对照受试者相比，FlFD 患者的额叶（不包括运动皮层）、双侧尾状核、岛叶和丘脑表现出显着的对称代谢减退。在随访中，我们观察到顶叶和颞叶皮质的葡萄糖代谢进一步显着降低。结论：在 FTD 的早期阶段，神经退行性过程仅限于额叶。在疾病进展过程中，病理变化越过脑叶边界并扩散到顶叶和颞叶皮质。 (c) 2005 Elsevier Inc. 保留所有权利。
Objective: To identify the pattern of progression of decline of cerebral glucose metabolism in frontotemporal dementia (FTD, frontal variant).Methods: 22 patients with mild FTD underwent 18F-FDG-positron emission tomography at baseline and at follow-up in average 19.5 months later. Patient scans were compared with scans from 15 healthy age-matched control subjects on a voxel-by-voxel basis using SPM-99.Results: As compared with healthy control subjects at baseline patients with FlFD showed a significant symmetrical hypometabolism of the frontal lobes sparing the motor cortex, of the caudate nuclei, insula and thalamus bilaterally. At follow-up further significant reductions in glucose metabolism were observed in the parietal and temporal cortices.Conclusions: In early stages of FTD the neurodegenerative process is limited to the frontal lobes. During the progression of the disease, the pathological changes pass over the lobar borders and spread into the parietal and temporal cortices. (c) 2005 Elsevier Inc. All rights reserved.