Enantiospecificity of Cysteine Adsorption on a Ferromagnetic Surface: Is It Kinetically or Thermodynamically Controlled?
Enantiospecificity of Cysteine Adsorption on a Ferromagnetic Surface: Is It Kinetically or Thermodynamically Controlled?
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DOI：
10.1021/acs.jpclett.1c02087
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发表时间：
2021-08-12
影响因子：
5.7
通讯作者：
Waldeck, D. H.
中科院分区：
文献类型：
--
作者：
Lu, Y.;Bloom, B. P.;Waldeck, D. H.
这项工作使用电化学石英晶体微天平方法来演示磁化表面和手性氨基酸之间的对映专一性相互作用。手性分子(以半胱氨酸为模型)在铁磁表面的对映吸附是由吸附动力学而不是热力学稳定性引起的。不同手性形式的半胱氨酸和不同的电极磁化状态的吸附自由能没有显著差异，而吸附和脱附动力学的测量表明，电极表面的磁化状态对吸附自由能有很强的依赖性。此外，对映体的选择性与溶液的pH和手性吸附物的荷电状态有关。
This work uses electrochemical quartz crystal microbalance methods to demonstrate the enantiospecific interaction between a magnetized surface and a chiral amino acid. The enantiospecific adsorption of chiral molecules (cysteine is used as a model) on a ferromagnetic surface is shown to arise from the kinetics of adsorption and not from a thermodynamic stabilization. Measurements of the Gibbs free energy of adsorption for different chiral forms of cysteine and different electrode magnetization states show no significant differences, whereas measurements of the adsorption and desorption kinetics reveal a strong dependence on the magnetization state of the electrode surface. In addition, the enantioselectivity is shown to depend sensitively on the solution pH and the charge state of the chiral adsorbate.