Donor age and recipient age.
Donor age and recipient age.
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捐赠者年龄和接受者年龄。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
P. Terasaki
中科院分区：
文献类型：
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作者：
S. Takemoto;P. Terasaki
供体的年龄。1. 老年供者肾脏移植存活率明显低于年轻供者肾脏移植存活率。16岁、50岁和65岁首次尸体移植肾1年生存率分别为80%、70%和57%。这意味着50岁供者的1年移植物存活率下降10%，65岁供者的1年移植物存活率下降23%。2. 1985年以后，年龄较大的供者移植物存活率降低的趋势最为明显，这表明CsA治疗是造成这种效果的主要原因。3. 50岁以上捐赠者的肾脏中有12%从未起过作用，而17岁至30岁捐赠者的肾脏无功能的比例仅为2%。46%的年轻捐赠者的肾脏在3天内起作用，而26%的50岁以上捐赠者的肾脏在3天内起作用。4. 在过去10年里，使用老年捐赠者的趋势逐渐增加。1978年，50岁以上的捐献者占捐献者的5%，到1987年上升到10%。5. 输血、HLA-B、DR错配和失败原因与供者年龄无关。6. 在过去10年进行的移植中，供体年龄对患者或移植物的存活都没有显著影响。这是否适用于最近的csa治疗移植还有待观察。接受者的年龄。1. 自1983年以来，受者年龄对患者存活率的影响最为显著：6- 7岁受者的存活率从100%下降到68- 71岁受者的86%。2. 50岁以上的患者接受移植的趋势增加。这个数字从1978年的14%上升到1987年的25%。3. 在接受者年龄的增加与相应的免疫功能衰竭的减少和非免疫功能衰竭的增加之间存在非常强的关联。对同种异体移植物的免疫反应性随着年龄的增长而下降，尽管非免疫原因的失败随着年龄的增长而增加。4. 不输血的患者随着年龄的增长移植物存活率越来越高：20岁以下患者的1年移植物存活率为63%，50岁以上患者的1年移植物存活率为73%，这与上述发现一致。输血使所有组的1年移植物存活率约为76%。因此，输血对老年受者的影响较小。（摘要删节为400字）
Donor age. 1. Kidneys from older donors led to markedly lower graft survival than kidneys from younger donors. The 1-year first cadaver donor graft survival rates were 80% for recipients receiving kidneys from 16-year-old donors, 70% from 50-year olds and 57% from 65-year-old donors. This means that 1-year graft survival decreased 10% by donor age 50 and 23% by donor age 65. 2. The trend toward lower graft survival with older donors was most noticeable after 1985, suggesting that CsA treatment was primarily responsible for the effect. 3. Twelve percent of kidneys from donors over age 50 never functioned while the nonfunction rate of 17- to 30-year-old donor kidneys was only 2%. Forty-six percent of kidneys from younger donors functioned within 3 days, whereas 26% functioned in 3 days if they came from donors who were older than 50. 4. The tendency to use older donors has gradually increased in the past 10 years. Donors over 50 years of age comprised 5% of the donors in 1978 and rose to 10% by 1987. 5. Transfusions, HLA-B,DR mismatches, and causes of failure were not related to donor age. 6. In transplants performed in the last 10 years, donor age did not play a significant role in either patient or graft survival. Whether or not this will hold true for more recent CsA-treated transplants remains to be seen. Recipient age. 1. The most significant effect of recipient age for patients transplanted since 1983 was on patient survival: it dropped from 100% for 6- to 7-year-old recipients to 86% for 68- to 71-year olds. 2. There is an increased tendency to transplant patients older than 50. The number rose from 14% in 1978 to 25% in 1987. 3. A very strong association was noted between advancing recipient age and corresponding decrease in immunologic failures and increase in nonimmunologic failures. Immunologic responsiveness to allografts decreased with age, though failures from nonimmunologic causes increased with age. 4. Patients with no transfusions had increasingly higher graft survival with age: 63% 1-year graft survival for patients up to 20 years old and 73% for those over 50 which was consistent with the above findings. Transfusions led to 1-year graft survival of about 76% in all groups. Thus, transfusions had less effect in older recipients.(ABSTRACT TRUNCATED AT 400 WORDS)