SYNAPTIC LOCALIZATION OF STRIATAL NMDA, QUISQUALATE AND KAINATE RECEPTORS
SYNAPTIC LOCALIZATION OF STRIATAL NMDA, QUISQUALATE AND KAINATE RECEPTORS
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DOI：
10.1016/0304-3940(89)90519-3
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发表时间：
1989-06-19
影响因子：
2.5
通讯作者：
YOUNG, AB
中科院分区：
文献类型：
--
作者：
GREENAMYRE, JT;YOUNG, AB
标记的谷氨酸与N-甲基-D-天冬氨酸（NMDA）受体D，L-α-谷氨酸的纹状体结合在单侧皮质剥除或单侧纹状体喹啉酸损伤的大鼠中检测了氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）对使君子酸受体和红藻氨酸对红藻氨酸受体的影响。去皮质后一周，与病变对侧纹状体相比，病变同侧纹状体中NMDA、使君子酸或红藻氨酸受体无显著变化。相比之下，结合到NMDA受体减少了92%，使君子酸受体减少了80%，红藻氨酸受体减少了81%，在纹状体喹啉酸损伤后3个月。NMDA受体结合的减少显著大于使君子酸或红藻氨酸受体的损失。这些结果表明，NMDA，使君子酸和红藻氨酸受体识别位点位于突触后的纹状体。这些结果对亨廷顿病的喹啉酸模型也有意义。
Striatal binding of labeled glutamate to N-methyl-D-aspartate (NMDA) receptors, D,L-.alpha.-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) to quisqualate receptors and kainate to kainate receptors was examined in rats which had received unilateral decortications or unilateral striatal quinolinic acid lesions. One week after decortication, there were no significant changes in NMDA, quisqualate or kainate receptors in the striatum ipsilateral to the lesion, when compared to the striatum contralateral to the lesion. In contrast, binding to NMDA receptors was reduced by 92%, to quisqualate receptors by 80% and to kainate receptors by 81% in striatum 3 months after quinolinic acid lesions. The reduction in NMDA receptor binding was significantly greater than the loss of quisqualate or kainate receptors. These results suggest that NMDA, quisqualate and kainate receptor recognition sites are located postsynaptically in the striatum. These results also have implications for the quinolinic acid model of Huntington''s disease.