Effect of Vitamin B2-Deficient Diet on Hydroxyproline- or Obesity-Induced Hyperoxaluria in Mice
Effect of Vitamin B2-Deficient Diet on Hydroxyproline- or Obesity-Induced Hyperoxaluria in Mice
复制标题
缺乏维生素 B2 的饮食对羟脯氨酸或肥胖引起的小鼠高草酸尿症的影响
DOI：
10.1002/mnfr.202100226
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Takahashi A.
中科院分区：
文献类型：
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作者：
Uebanso T;Suyama M;Shimohata T;Mawatari K;Takahashi A.
肾结石的病因有哪些？哺乳动物体内大约一半的草酸盐来自饮食，另一半是由乙醛酸内源性合成的。降低肝乙醇酸氧化酶（GO）活性是减少草酸内源性产生的一种方法。然而，目前降低肝脏GO活性的有效饮食方法很少。方法与结果本研究探讨限制膳食维生素B2（VB 2）是否可以降低羟脯氨酸（Hyp）诱导的高草酸尿症小鼠肝脏GO活性和草酸盐排泄。或肥胖。发现VB2限制显著降低了Hyp和肥胖诱导的小鼠高尿酸模型中的肝GO活性。然而，VB2限制仅在Hyp处理的小鼠中减少尿草酸盐排泄，而在肥胖小鼠中不减少。这种差异可能是由于贡献的内源性草酸的生产，表现为增加肝GO活性在Hyp处理的小鼠，但不肥胖mice.ConclusionTogether这些结果表明，VB2限制可能是一种新的饮食方法，以改善高血压尿时，内源性生产的草酸增加。
ScopeHyperoxaluria is a major cause of kidney stone disease. Around half of the oxalate in mammals is supplied from the diet and the other half is endogenously synthesized from glyoxylate. Reduction of hepatic glycolate oxidase (GO) activity is one approach to reduce endogenous production of oxalate. However, there are currently few effective dietary approaches to reduce hepatic GO activity.Methods and ResultsIn the present study, it is investigated whether restriction of dietary vitamin B2 (VB2) can reduce hepatic GO activity and oxalate excretion in mice with hyperoxaluria induce by hydroxyproline (Hyp) or obesity. It is found that VB2 restriction significantly reduces hepatic GO activity in both the Hyp‐ and obesity‐induced model of hyperoxaluria in mice. However, VB2 restriction reduces urinary oxalate excretion only in the Hyp‐treated mice and not the obese mice. This difference could be due to the contribution of endogenous oxalate production that manifests as increased hepatic GO activity in Hyp‐treated mice but not obese mice.ConclusionTogether these results suggest that VB2 restriction could be a new dietary approach to improve hyperoxaluria when endogenous production of oxalate is increased.