Carotid and femoral arterial wall changes and the prevalence of clinical cardiovascular disease
Carotid and femoral arterial wall changes and the prevalence of clinical cardiovascular disease
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DOI：
10.1177/1358863x08101542
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发表时间：
2009-08-01
影响因子：
3.5
通讯作者：
Fessas, Charris
中科院分区：
文献类型：
--
作者：
Griffin, Maura;Nicolaides, Andrew;Fessas, Charris
塞浦路斯研究是一项心血管疾病（CVD）的前瞻性队列研究。其目的是确定颈总动脉内膜-中层厚度（IMT）（IMTcc）、颈动脉分叉处IMT最大厚度（IMTmax）、颈动脉和股动脉分叉处斑块数量和总斑块厚度（TPT）（扫描四个分叉处获得的最大斑块测量值之和）与临床CVD患病率的关系。从首都尼科西亚外的一个山村和一个城镇招募了767名40岁以上的人（46%为男性）。除了临床检查，颈动脉和股总动脉分叉进行了超声扫描。在控制了传统的危险因素后，几乎没有证据表明IMTcc与CVD患病率相关。然而，IMTmax和TPT分别与CVD患病率增加2.9倍（1.22至7.07）和6.87倍（2.42至19.43）相关。总之，TPT和斑块分叉数与CVD的患病率更密切相关。这些发现值得在前瞻性研究中进行调查，以记录与CVD事件的相关性。
The Cyprus Study is a prospective cohort study of cardiovascular disease (CVD). Its aim is to determine the relationship of intima-media thickness (IMT) of the common carotid (IMTcc), maximum thickness of IMT in the carotid bifurcation (IMTmax), number of carotid and femoral bifurcations with plaque and total plaque thickness (TPT) (sum of the maximum plaque measurements taken from the four bifurcations scanned) with the prevalence of clinical CVD. A total of 767 individuals (46% male) over the age of 40 years were recruited from a mountain village and a town outside the capital Nicosia. In addition to clinical examination, carotid and common femoral bifurcations were scanned with ultrasound. After controlling for conventional risk factors, there was little evidence of an association of IMTcc with CVD prevalence. However, IMTmax and TPT were associated with 2.9-fold (1.22 to 7.07) and 6.87-fold (2.42 to 19.43) increased odds of CVD prevalence, respectively. In conclusion, the TPT and number of bifurcations with plaque are more strongly associated with the prevalence of CVD. These findings warrant investigation in prospective studies to document associations with incident CVD events.