Kisspeptin in the medial amygdala and sexual behavior in male rats.
Kisspeptin in the medial amygdala and sexual behavior in male rats.
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DOI：
10.1016/j.neulet.2016.05.042
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发表时间：
2016-08-03
影响因子：
2.5
通讯作者：
O'Byrne KT
中科院分区：
文献类型：
--
作者：
Gresham R;Li S;Adekunbi DA;Hu M;Li XF;O'Byrne KT
大鼠背内侧杏仁核内的Kisspeptin可引起交配前勃起。其机制是kisspeptin受体特异性的。Kisspeptin诱导的GnRH和LH释放不受影响。内侧杏仁核（MeA）对性行为至关重要; kisspeptin（Kiss 1）也在性功能中发挥作用。Kisspeptin受体（Kiss 1 r）敲除小鼠没有性行为。近年来，在内侧杏仁核背后亚核（Posterodoral subnucleus of medial amygdala，MePD）中发现了Kiss 1和Kiss 1 r的表达。我们假设MePD中的Kiss 1可能对男性性行为有影响。为了测试这一点，我们在雄性大鼠中双侧插管MePD并输注kisspeptin-10。这导致大鼠多次勃起，这是Kiss 1受体激活的特异性效应，因为Kiss 1 r拮抗作用阻断了勃起反应。当Kiss 1注入侧脑室时，没有观察到勃起。我们还测量了当Kiss 1注入MePD或侧脑室时的血浆LH水平;当Kiss 1注入这两个部位时，血浆LH增加到相当的水平。我们的结论是，Kiss 1在男性性行为中发挥作用，这是特定于MePD。
Kisspeptin in the posterodorsal medial amygdala evokes ex-copular erections in rats. The mechanism is kisspeptin receptor specific. Kisspeptin induced GnRH and LH release are not implicated. The medial amygdala (MeA) is crucial for sexual behavior; kisspeptin (Kiss1) also plays a role in sexual function. Kisspeptin receptor (Kiss1r) knockout mice display no sexual behavior. Recently Kiss1 and Kiss1r have been discovered in the posterodorsal subnucleus of the medial amygdala (MePD). We hypothesised that Kiss1 in the MePD may have an influence on male sexual behavior. To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats. This caused the rats to have multiple erections, an effect specific to Kiss1 receptor activation, because Kiss1r antagonism blocked the erectile response. When Kiss1 was infused into the lateral cerebroventricle, there were no observed erections. We also measured the plasma levels of LH when Kiss1 is infused into the MePD or lateral cerebroventricle; Kiss1 increased plasma LH to comparable levels when infused into both sites. We conclude that Kiss1 has a role in male sexual behavior, which is specific to the MePD.