MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network
MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network
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DOI：
10.1016/j.ijid.2020.01.042
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发表时间：
2020-03-01
影响因子：
8.4
通讯作者：
Sotgiu, Giovanni
中科院分区：
文献类型：
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作者：
Migliori, Giovanni Battista;Tiberi, Simon;Sotgiu, Giovanni
关于耐多药结核病诊断、治疗、预防和康复的新研究文章不断涌现，需要经常更新现有指南。本次综述旨在为临床医生和公共卫生工作人员提供一份来自全球结核病网络（GTN）专家共识的最新且易于查阅的文件。对已发表的核心文件和指南进行了回顾，包括最近发布的耐多药结核病世界卫生组织快速建议和ATS/CDC/ERS/IDSA指南。在对流行病学和危险因素进行快速回顾后，确定了耐多药结核病诊断（包括全基因组测序和药敏试验解释）和治疗（治疗设计和治疗方案）的临床重点。管理、儿童结核病）进行了讨论。此外，该综述全面描述了耐多药结核病接触者的接触者追踪和LTBI管理的最新信息，同时为结核病后遗症的治疗后功能评估和康复、感染控制和其他公共卫生重点提供指导。 (C) 2020 作者。由爱思唯尔有限公司代表国际传染病学会出版。
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts.The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines.After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.