Vaccination against Schistosoma mansoni with purified surface antigens.
Vaccination against Schistosoma mansoni with purified surface antigens.
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用纯化的表面抗原接种曼氏血吸虫疫苗。
DOI：
10.1126/science.3966161
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发表时间：
1985
期刊：
影响因子：
56.9
通讯作者：
J. Clegg
中科院分区：
文献类型：
--
作者：
M. Smith;J. Clegg
用单克隆抗体进行亲和层析，从年轻或成年的嗜热小体中分离到两种表面抗原。用分子量为155，000的抗原接种疫苗在一些批次的小鼠和一组食蟹猴中提供了针对攻击的部分保护。用分子量为53，000的抗原接种疫苗在小鼠中产生类似水平的保护。结果表明，可以获得保护与单一抗原，但精确的要求，可重复的疫苗接种是未知的。
Two surface antigens were isolated from young or adult schistosomes by affinity chromatography with monoclonal antibodies. Vaccination with an antigen having a molecular weight of 155,000 gave partial protection against challenge in some batches of mice and in a group of cynomolgus monkeys. Vaccination with an antigen having a molecular weight of 53,000 gave similar levels of protection in mice. The results demonstrate that protection can be obtained with single antigens, but the precise requirements for reproducible vaccination are as yet unknown.