Red blood cell distribution width as a marker of cerebral infarction in hemodialysis patients
Red blood cell distribution width as a marker of cerebral infarction in hemodialysis patients
复制标题
红细胞分布宽度作为血液透析患者脑梗死的标志物
DOI：
10.1080/0886022x.2017.1398664
复制
发表时间：
2017-11-16
期刊：
影响因子：
3
通讯作者：
Liang, Xinling
中科院分区：
文献类型：
--
作者：
Mo, Liyi;Chen, Yuanhan;Liang, Xinling
摘要背景：红细胞分布宽度（RDW）是心血管生物标志物。我们评估了血液透析患者RDW与脑卒中风险之间的关系。方法：对442例成人血液透析患者进行队列研究。根据ICD-10诊断代码定义卒中。常规全血细胞计数，每3-6个月评估一次，用于RDW值。结果如下：在442例血液透析患者中，在50个月的随访中，有62例（14.0%）脑卒中：41例（9.3%）脑梗死，21例（4.8%）脑出血。与非脑卒中患者相比，脑卒中和脑梗死患者的RDW显著升高。而脑出血患者与非脑卒中患者的RDW无显著性差异。在不同的多变量考克斯回归模型中，经年龄、高血压、白蛋白、Charlson合并症评分和C反应蛋白校正后，平均RDW四分位数最高的患者发生脑梗死的风险是平均RDW四分位数最低的患者的2.55倍（风险比= 3.55; 95%置信区间：1.33-9.51）。RDW不是脑出血的独立危险因素。结论：RDW增加是血液透析患者发生脑梗死的独立危险因素。
Abstract Background: Red blood cell distribution width (RDW) is a cardiovascular biomarker. We evaluated the association between RDW and cerebral stroke risk in hemodialysis patients. Methods: A cohort of 442 adult patients on hemodialysis was studied. Strokes were defined according to ICD-10 diagnosis codes. Routine complete blood counts, evaluated every 3–6 months, were used for RDW values. Results: Among 442 hemodialysis patients, during the 50-month follow-up, there were 62 cases (14.0%) of cerebral stroke: 41 (9.3%) with cerebral infarction and 21 (4.8%) with cerebral hemorrhage. Compared with nonstroke patients, a significantly higher RDW was measured in patients with cerebral stroke and cerebral infarction. However, no significant difference was seen in RDW between patients with cerebral hemorrhage and nonstroke patients. After adjustment by age, hypertension, albumin, Charlson Comorbidity Score, and C-reactive protein in different multivariable Cox regression models, patients with the highest mean RDW quartile had a 2.55-fold (hazard ratio = 3.55; 95% confidence interval: 1.33–9.51) higher risk of developing cerebral infarction relative to those with the lowest mean RDW quartile. RDW was not an independent risk factor for cerebral hemorrhage. Conclusions: Increased RDW is an independent risk factor of cerebral infarction in hemodialysis patients.