Serum cystatin C, enzymuria, tubular proteinuria and early renal insult in type 2 diabetes
Serum cystatin C, enzymuria, tubular proteinuria and early renal insult in type 2 diabetes
复制标题
DOI：
10.1080/09674845.2007.11732770
复制
发表时间：
2007-01-01
影响因子：
1.9
通讯作者：
Whiting, P. H.
中科院分区：
文献类型：
--
作者：
Kalansooriya, A.;Holbrook, I.;Whiting, P. H.
本研究旨在探讨血清胱抑素C、血清肌酐浓度、N-乙酰-β-D-氨基葡萄糖苷酶（NAG酶尿症），尿α 1-微球蛋白（α 1-MG）和β 2-微球蛋白2型糖尿病受试者的β 2-MG水平（n=40，20 M/20 F，年龄范围25-65岁;糖尿病持续时间8-10年）和年龄和性别匹配的健康对照（n=20）。排除标准为无蛋白尿、高血压、血脂异常或心血管疾病。采集空腹血和中段尿，测定血肌酐、胱抑素C、尿肌酐、尿NAG酶、α 1-MG和β 2-MG。根据白蛋白：肌酐浓度比将糖尿病受试者分为两组。A组：
This study investigates the association between serum cystatin C, serum creatinine concentrations, N-acetyl-beta-D-glucosaminidase (NAG enzymuria), urine alpha 1-microglobulin (alpha 1-MG) and beta 2-microglobulin (beta 2-MG) levels in subjects with type 2 diabetes (n=40, 20M/20F, age range 25-65 years; duration of diabetes 8-10 years) and age- and gender-matched healthy controls (n=20). Exclusion criteria were absence of gross proteinuria, hypertension, dyslipidaemia or cardiovascular disease. Fasting blood samples and mid-stream specimen of urine (MSSU) were collected and serum creatinine, cystatin C, urine creatinine, NAG enzymuria, a1-MG and beta 2-MG were measured. Diabetic subjects were separated into two groups based on albumin: creatinine concentration ratio. Group A: