Nonenzymatic enantioselective synthesis of all-carbon quaternary centers through desymmetrization.
Nonenzymatic enantioselective synthesis of all-carbon quaternary centers through desymmetrization.
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DOI：
10.1016/j.tetlet.2015.09.134
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发表时间：
2015-11-25
影响因子：
1.8
通讯作者：
Petersen KS
中科院分区：
文献类型：
--
作者：
Petersen KS
含全碳四元中心的中间体或前手性化合物的不对称去对称化是一种很有吸引力的合成方法，其目的是不对称地形成新的C-C键。本文综述了利用过渡金属催化剂或有机催化剂来区分对映体基团以生成含全碳四元立体中心的富含对映体化合物的非酶去对称化反应。
The asymmetric desymmetrization of meso or prochiral compounds containing an all-carbon quaternary center is an attractive alternative to classical synthetic approaches aimed at the asymmetric formation of a new C—C bond. This review focuses on nonenzymatic desymmetrizations that utilize transition metal catalysts or organocatalysts to distinguish between enantiotopic groups to generate enantioenriched compounds containing all-carbon quaternary stereocenters.