Investigating the potential role of multi-drug resistance protein (MRP) transporters in fetal to maternal glyburide efflux in the human placenta
Investigating the potential role of multi-drug resistance protein (MRP) transporters in fetal to maternal glyburide efflux in the human placenta
复制标题
研究多药耐药蛋白（MRP）转运蛋白在人胎盘中胎儿至母体格列本脲外流中的潜在作用
DOI：
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发表时间：
2008
影响因子：
1.6
通讯作者：
Gideon Koren
中科院分区：
文献类型：
--
作者：
C. Gedeon;G. Anger;A. Lubetsky;M. P. Miller;Gideon Koren
摘要 格列本脲是一种用于治疗妊娠糖尿病的药物，此前已被证明在胎儿血液中无法测量到，并且会以浓度梯度从胎儿转移到母体循环中。该研究的目的是确定吲哚美辛（一种多药耐药家族（MRP）转运蛋白的抑制剂）是否参与格列本脲从胎儿到母亲的主动流出。使用双灌注人胎盘子叶模型，同时进行格列本脲和吲哚美辛的 12 次灌注。在存在抑制剂的情况下格列本脲的转移速率与在不存在抑制剂的情况下格列本脲的转移速率没有不同。此外，我们的研究表明，MRP1、2 或 3 可能仅最低限度地参与格列本脲跨人类胎盘的转运。这些结果提出了其他 ABC 转运蛋白，例如格列本脲胎盘转移的可能候选蛋白。
Summary Glyburide, a drug used to treat gestational diabetes has previously been shown not to be measurable in fetal blood, and to be transferred from the fetal to the maternal circulation against a concentration gradient. The objective of the study is to determine whether indomethacin, an inhibitor of the multi-drug resistance family (MRP) of transporters is involved in the active efflux of glyburide from the fetus to the mother. Using the dually perfused human placental cotyledon model, 12 perfusions were performed of both glyburide and indomethacin concomitantly. The rate of transfer of glyburide in the presence of inhibitor was not different from the rate of transfer of glyburide in the absence of inhibitor. Furthermore, our study suggests that MRP1, 2 or 3 may be only minimally involved in the transport of glyburide across the human placenta. These results pose other ABC transporters, such as likely candidates for the placental transfer of glyburide.
1-[2-[双-(4-氟苯基)甲氧基]乙基]哌嗪 (GBR 12909) 的进一步探索：N-芳香族、N-杂芳香族和 3-氧化 N-苯基丙基取代基对多巴胺和亲和力的作用
影响因子：
2.7
作者：
Lewis,David;Zhang,Ying;Prisinzano,Thomas;Dersch,ChristinaM;Rothman,RichardB;Jacobson,ArthurE;Rice,KennerC
通讯作者：
Rice,KennerC
纯化的人胎盘刷状缘膜囊泡中的钙使牛磺酸转运蛋白失活。
影响因子：
3.8
作者：
Kulanthaivel,P;Miyamoto,Y;Mahesh,VB;Leibach,FH;Ganapathy,V
通讯作者：
Ganapathy,V
体外人胎盘：双重灌注 12 小时期间的表征。
DOI：
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发表时间：
1985
期刊：
Contributions to gynecology and obstetrics
影响因子：
--
作者：
Miller,RK;Wier,PJ;Maulik,D;diSant'Agnese,PA
通讯作者：
diSant'Agnese,PA