eIF3 interacts with histone H4 messenger RNA to regulate its translation.
eIF3 interacts with histone H4 messenger RNA to regulate its translation.
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DOI：
10.1016/j.jbc.2021.100578
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Allmang C
中科院分区：
文献类型：
--
作者：
Hayek H;Gross L;Janvier A;Schaeffer L;Martin F;Eriani G;Allmang C
In eukaryotes, various alternative translation initiation mechanisms have been unveiled for the translation of specific mRNAs. Some do not conform to the conventional scanning-initiation model. Translation initiation of histone H4 mRNA combines both canonical (cap-dependent) and viral initiation strategies (no-scanning, internal recruitment of initiation factors). Specific H4 mRNA structures tether the translation machinery directly onto the initiation codon and allow massive production of histone H4 during the S phase of the cell cycle. The human eukaryotic translation initiation factor 3 (eIF3), composed of 13 subunits (a-m), was shown to selectively recruit and control the expression of several cellular mRNAs. Whether eIF3 mediates H4 mRNA translation remains to be elucidated. Here, we report that eIF3 binds to a stem-loop structure (eIF3-BS) located in the coding region of H4 mRNA. Combining cross-linking and ribonucleoprotein immunoprecipitation experiments in vivo and in vitro, we also found that eIF3 binds to H1, H2A, H2B, and H3 histone mRNAs. We identified direct contacts between eIF3c, d, e, g subunits, and histone mRNAs but observed distinct interaction patterns to each histone mRNA. Our results show that eIF3 depletion in vivo reduces histone mRNA binding and modulates histone neosynthesis, suggesting that synthesis of histones is sensitive to the levels of eIF3. Thus, we provide evidence that eIF3 acts as a regulator of histone translation.
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DOI：
10.1098/rstb.2016.0176
发表时间：
2017-03-19
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Cate JH
通讯作者：
Cate JH
影响因子：
16.6
作者：
de la Parra C;Ernlund A;Alard A;Ruggles K;Ueberheide B;Schneider RJ
通讯作者：
Schneider RJ
DOI：
10.1083/jcb.200708110
发表时间：
2008-02-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Boulon S;Marmier-Gourrier N;Pradet-Balade B;Wurth L;Verheggen C;Jády BE;Rothé B;Pescia C;Robert MC;Kiss T;Bardoni B;Krol A;Branlant C;Allmang C;Bertrand E;Charpentier B
通讯作者：
Charpentier B
影响因子：
5.6
作者：
Cai, Qi;Todorovic, Aleksandar;Cate, Jamie H. D.
通讯作者：
Cate, Jamie H. D.
影响因子：
16
作者：
Fortes, P;Inada, T;Sachs, AB
通讯作者：
Sachs, AB