A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional study
A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional study
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DOI：
10.1016/j.annepidem.2005.10.007
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发表时间：
2006-07-01
影响因子：
5.6
通讯作者：
Kaaks, Rudolf
中科院分区：
文献类型：
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作者：
Hunt, Kelly J.;Lukanova, Annekatrin;Kaaks, Rudolf
目得：循环中胰岛素样生长因子I（IGF-I）水平升高越来越多地被认为是某些癌症发生的潜在风险因素;然而，相对较少的流行病学研究关注循环IGF-I水平与心血管风险因素或心血管疾病之间的潜在关系。因此，我们的目标是研究IGF-I水平之间的关系;体重指数（BMI）;空腹胰岛素水平; IGF结合蛋白1（IGFBP-1），IGFBP-2，IGFBP-3水平;和一系列传统的心血管危险因素。方法：我们的分析包括715名男性和女性，年龄在30至62岁谁参加了Vasterbotten干预项目队列。在储存的血浆样品中测量IGF-1和IGFBP-1、-2和-3。感兴趣的心血管风险因素包括血糖水平（空腹和负荷后2小时）。血脂水平（总胆固醇、高密度脂蛋白胆固醇和甘油三酯）、血压（收缩压和舒张压）和高血压状态。所有的结果都根据年龄、性别和实验室批次进行了调整。结果：IGF-1四分位数与2小时血糖水平和舒张压呈负相关。IGF-I四分位数的增加与高血压之间存在逐步的反相关性，第四个IGF-I四分位数与第一个IGF-I四分位数相比，高血压的优势比为0.51（95%置信区间，0.29-0.90）。进一步调整BMI和IGFBP-3水平同时加强了负相关，比值比为0.42（95%置信区间，0.22-0.80）高血压比较第四与第一四分位数IGF-I。与IGF-I水平与某些癌症之间的正相关相反，我们的研究结果表明IGF-I水平可能与高血压患病率呈负相关，心血管疾病的危险因素。
PURPOSE: Elevated circulating insulin-like growth factor I (IGF-I) levels increasingly are being implicated as a potential risk factor for the development of some cancers; however, relatively few epidemiologic Studies have focused on potential relationships between circulating IGF-I levels an cardiovascular risk factors or cardiovascular disease. Hence, our objective is to examine relationships between IGF-I levels; body mass index (BMI); fasting insulin level; IGF binding protein 1 (IGFBP-1), IGFBP-2, and IGFBP-3 levels; and an array of traditional cardiovascular risk factors.METHODS: Our analysis included 715 men and women aged 30 to 62 years who participated in the Vasterbotten Intervention Project cohort. IGF-1 and IGFBP-1, -2, and -3 were measured in stored plasma samples. Cardiovascular risk factors of interest included glucose level (fasting and 2-hour postload). lipid levels (total cholesterol, high-density lipoprotein cholesterol, and triglycerides), blood pressure (systolic and diastolic), and hypertension status. All presented results were adjusted for age, sex, and laboratory batch.RESULTS: IGF-1 quartile was associated inversely with 2-hour glucose level and diastolic blood pressure. There was a stepwise inverse graded association between increasing IGF-I quartile and hypertension, with an odds ratio of 0.51 (95% confidence interval, 0.29-0.90) for hypertension comparing the fourth IGF-I quartile with the first. Further adjusting for BMI and IGFBP-3 level simultaneously strengthened the inverse association, with an odds ratio of 0.42 (95% confiderice interval, 0.22-0.80) for hypertension comparing the fourth With the first IGF-I quartile.CONCLUSIONS: Contrary to positive associations between IGF-I levels and some cancers, Our results suggest that IGF-I level may be related inversely to prevalent hypertension, a risk factor for cardiovascular disease.