EXERCISE, DOBUTAMINE, AND COMBINED ATROPINE, NOREPINEPHRINE, AND EPINEPHRINE COMPARED
EXERCISE, DOBUTAMINE, AND COMBINED ATROPINE, NOREPINEPHRINE, AND EPINEPHRINE COMPARED
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DOI：
10.1152/jappl.1985.58.6.2047
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
MITCHELL, JH
中科院分区：
文献类型：
--
作者：
HAIDET, GC;MUSCH, TI;MITCHELL, JH
比较的是：通过次最大运动在清醒狗中诱发的心血管效应; kg-1. min-1）;和输注阿托品（0.15 mg/kg）、去甲肾上腺素（0.19 μ g. kg-1. min-1）和肾上腺素（0.05 μ g. kg-1. min ~（-1）。心肌O2需求，如通过双乘积（心率×心率）估计的。收缩压），在所有3次干预期间相似。3种干预措施均使心输出量和心率显著增加（P < 0.05）。然而，动静脉O2差和全身O2消耗量仅在次极量运动期间增加。虽然心肌血流量在3种干预措施中的每一种都有类似的增加，但骨骼肌和舌头的血流量仅在运动期间增加。运动和阿托品、去甲肾上腺素和肾上腺素的联合输注产生了类似的横膈膜血流量增加和类似的胃血流量减少。这些血流变化与血管阻力的适当变化相关。在3次干预中，流向大脑、肾脏、肾上腺、肝脏和肠道的血流均未发生变化。在犬中，亚极量运动、多巴酚丁胺输注和阿托品、去甲肾上腺素和肾上腺素组合输注以引起给定水平的估计心肌O2消耗，可产生类似的心输出量、心率和心肌血流量增加。在这两种干预中，全身耗氧量、动静脉氧差、局部血流量和局部血管阻力的变化各不相同。
Compared were: the cardiovascular effects evoked in conscious dogs by submaximal exercise; infusion of dobutamine (40 .mu.g .cntdot. kg-1 .cntdot. min-1); and infusion of a combination of atropine (0.15 mg/kg), norepinephrine (0.19 .mu.g .cntdot. kg-1 .cntdot. min-1) and epinephrine (0.05 .mu.g .cntdot. kg-1 .cntdot. min-1). Myocardial O2 demand, as estimated by the double product (heart rate .times. systolic blood pressure), was similar during all 3 interventions. Cardiac output and heart rate increased significantly (P < 0.05) during each of the 3 interventions. Arteriovenous O2 difference and total body O2 consumption, however, increased only during submaximal exercise. Although myocardial blood flow increased similarly during each of the 3 interventions, blood flow to skeletal muscle and the tongue increased only during exercise. Exercise and the combined infusion of atropine, norepinephrine and epinephrine produced similar increases in blood flow to the diaphragm and similar decreases in blood flow to the stomach. These changes in blood flow were associated with appropriate changes in vascular resistance. Blood flow to the brain, kidney, adrenal glands, liver and intestine did not change during any of the 3 interventions. In dogs, submaximal exercise, infusion of dobutamine and infusion of a combination of atropine, norepinephrine and epinephrine to evoke a given level of estimated myocardial O2 consumption produce similar increases in cardiac output, heart rate and myocardial blood flow. The changes in total body O2 consumption, arteriovenous O2 difference, regional blood flow and regional vascular resistance that occur during each of these 2 interventions are different.