A RECEPTOR FOR PROTONS IN THE MEMBRANE OF SENSORY NEURONS MAY PARTICIPATE IN NOCICEPTION
A RECEPTOR FOR PROTONS IN THE MEMBRANE OF SENSORY NEURONS MAY PARTICIPATE IN NOCICEPTION
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DOI：
10.1016/0306-4522(81)90105-6
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发表时间：
1981-01-01
期刊：
影响因子：
3.3
通讯作者：
PIDOPLICHKO, VI
中科院分区：
文献类型：
--
作者：
KRISHTAL, OA;PIDOPLICHKO, VI
采用细胞内灌流和电压钳技术对分离的大鼠三叉神经节神经元进行研究。他们测试了最近发现的质子激活钠电导机制的存在。在实验之前测量每个测试细胞的直径。由于伤害性冲动主要由细神经纤维携带，并且已知感觉神经元的神经纤维的直径与神经细胞体的大小成正比，因此参与伤害性感受的大多数神经元的尺寸必须很小。近一半的三叉神经节神经元被发现是质子敏感的。大部分（74%）的神经元可以归类为小（直径小于26 μm）。75%的质子不敏感细胞直径大于26 μm，表明质子感受器参与了伤害性感受。三种类型的脱敏动力学的质子受体。
Neurons isolated from rat trigeminal ganglia were investigated by intracellular perfusion and voltage clamp. They were tested for the existence of a recently discovered proton-activated sodium conductance mechanism. The diameter of each cell tested was measured before the experiment. Since the nociceptive impulses are carried mainly by the thin nerve fibers and the diameter of the nerve fiber of a sensory neuron is known to be directly proportional to the size of the nerve cell body the dimensions of the majority of the neurons participating in nociception must be small. Nearly half of the trigeminal ganglia neurons were found to be proton-sensitive. The majority (74%) of such neurons could be classified as small (smaller than 26 μm in diameter). 75% of the proton-insensitive cells were larger than 26 μm in diameter.It is suggested that the receptor for protons has a part in nociception. Three types of desensitization kinetics of the proton receptor are described.