Direct Metal- and Reagent-Free Sulfonylation of Phenols with Sodium Sulfinates by Electrosynthesis
Direct Metal- and Reagent-Free Sulfonylation of Phenols with Sodium Sulfinates by Electrosynthesis
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DOI：
10.1002/chem.201900850
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发表时间：
2019-05-17
影响因子：
4.3
通讯作者：
Waldvogel, Siegfried R.
中科院分区：
文献类型：
--
作者：
Nikl, Joachim;Lips, Sebastian;Waldvogel, Siegfried R.
开发了一种通过苯酚与亚磺酸钠直接磺酰化合成芳基砜的新型电化学策略。 C,S-偶联产品特别适合化学合成、材料科学和制药科学。通过使用这种无金属和试剂的电化学方法，可以直接以良好的产率获得芳基和二芳基砜。所建立的一步协议易于执行、可扩展、本质安全，并且适用范围广泛，不受醌型形成底物的限制。
A novel electrochemical strategy for the synthesis of aryl sulfones by direct sulfonylation of phenols with sodium sulfinates has been developed. The C,S-coupling products are of particular interest for chemical synthesis, material sciences and pharmaceutical sciences. By using this metal-and reagent-free electrochemical method, aryl and diaryl sulfones can be obtained directly in good yields. The established one-step protocol is easy to perform, scalable, inherently safe, and enables a broad scope, which is not limited by quinoid-forming substrates.