Two- to sixfold decreased odds of HIV risk behavior associated with use of syringe exchange
Two- to sixfold decreased odds of HIV risk behavior associated with use of syringe exchange
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DOI：
10.1097/00126334-200210010-00015
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发表时间：
2002-10-01
影响因子：
3.6
通讯作者：
Guydish, J
中科院分区：
文献类型：
--
作者：
Gibson, DR;Brand, R;Guydish, J
我们报告了一项关于注射器交换的社区研究结果，该研究比较了交换客户与非客户的HIV风险行为。对259名未经治疗的注射毒品使用者（IDUs）的前瞻性队列进行了基线后平均10.7个月的随访。在评估随访时的HIV风险行为是否与研究参与者的后续交换使用相关时，我们控制了他们的基线风险行为和交换使用，作为风险承担倾向的标志，以及其他潜在的混杂因素。我们还研究了是否有一个不同的好处交换使用注射吸毒者与那些没有获得其他来源的注射器。单变量和多变量分析均显示，与使用交换相关的HIV风险行为的几率降低了两倍以上。在第二个多变量分析中，检查了交换使用与获得其他注射器来源的相互作用，没有其他来源的注射吸毒者的艾滋病毒风险行为的几率降低了六倍以上。我们的结论是，使用交换有很大的保护作用，对艾滋病毒的危险行为，可能是特别重要的注射吸毒者没有其他来源的注射器。
We report results of a community study of syringe exchange that compared the HIV risk behavior of exchange clients with that of nonclients. A prospective cohort of 259 untreated injecting drug users (IDUs) was followed a mean of 10.7 months after baseline. In assessing whether HIV risk behavior at follow-up was associated with study participants' follow-up use of the exchange, we controlled their baseline risk behavior and exchange use as markers of risk-taking tendency in addition to other potential confounders. We also examined whether there was a differential benefit of exchange use for IDUs with versus those without access to other sources of syringes. Both univariate and multivariate analyses revealed a more than twofold decreased odds of HIV risk behavior associated with use of the exchange. In a second multivariate analysis, which examined the interaction of exchange use with access to other sources of syringes, the odds of HIV risk behavior were decreased more than sixfold for IDUs without other sources. We conclude that use of the exchange had a substantial protective effect against HIV risk behavior and may have been especially critical for IDUs without other sources of syringes.