Optical visualization of blood shear stress using laser Doppler velocimetry combined with acousto-optic module
Optical visualization of blood shear stress using laser Doppler velocimetry combined with acousto-optic module
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DOI：
10.1016/j.optcom.2020.126607
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发表时间：
2021-03-15
影响因子：
2.4
通讯作者：
Hachiga, Tadashi
中科院分区：
文献类型：
--
作者：
Tajiri, Tomoki;Kyoden, Tomoaki;Hachiga, Tadashi
声光调制器（AOM）与双光束多点激光多普勒测速仪（MLDV）结合使用，以实现先进的血流观察，同时确定血流速度的大小和方向。为了测量血管壁周围的剪切应力，特别是在阻塞物附近的区域中，使用AOM结合双光束MLDV（AOM-MLDV）测量脉动血流中的剪切速率（速度梯度）。此外，使用旋转粘度计测量血液粘度以估计剪切应力。基于测量结果，剪切应力可以被估计为粘度和剪切速率的乘积，其由速度分布确定。发现血流速度在流动通道中的阻塞周围区域中增加。AOM-MLDV结果表明，障碍物形成了复杂的流动，障碍物周围的剪切应力达到峰值。本文提出了一种新的血流检测系统，提供实时状态确定能力，使用声光调制和LDV。
An acousto-optic modulator (AOM) was used in combination with two-beam multipoint laser Doppler velocimetry (MLDV) to achieve advanced blood flow observation for simultaneous determination of the magnitude and direction of the blood flow velocity. To measure the shear stress around the blood vessel wall, especially in regions near obstructions, the shear rate (velocity gradient) in a pulsatile blood flow was measured using the AOM in combination with two-beam MLDV (AOM-MLDV). In addition, the blood viscosity was measured using a rotating viscometer for the estimation of shear stress. Based on the measurement results, the shear stress could be estimated as the product of the viscosity and the shear rate, which was identified determined from the velocity distribution. The blood flow velocity was found to increase in the region around the obstruction in the flow channel. Complex flows formed as a result of the obstruction, and the shear stress was observed to reach a peak value around the obstruction based on the AOM-MLDV results. This paper presents a novel blood flow detection system that provides real-time state determination capabilities using acousto-optic modulation and LDV.