A century of asthma.
A century of asthma.
复制标题
一个世纪的哮喘病。
DOI：
10.1164/rccm.200402-185oe
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发表时间：
2004
影响因子：
24.7
通讯作者：
McFaddenJr,ER
中科院分区：
文献类型：
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作者：
McFaddenJr,ER
总结美国胸科学会(ATS)一生中哮喘的病史是一项具有挑战性的任务。1904年，当该学会成立时，美国陆军总医务长办公室的索引目录(当时的索引Medicus)列出了33条引文和3本关于这个主题的书籍。相比之下，2000年发表了3090篇关于哮喘的文章，国会图书馆增加了191本新书。这种增长的故事值得一讲，因为它代表了临床敏锐的最佳状态，与热衷于使用新兴技术以及治疗试验和错误相结合。因为调查人员是医生，减轻患者的不适往往优先于了解因果关系的必要性，因此，一些真正了不起的治疗方法被尝试了。直到二十世纪后半叶，病理生理学、免疫生物学和药理学的进展才开始并行，并取得了坚实的认识。这篇简短的回顾试图展示什么是ATS开始的时候知道的，以及我们是如何到达今天的地步的。它主要处理过去15-20年的事件，因为这些信息足够成熟，经得起时间的考验。关于哮喘的最新想法将在适当的地方编目，但它们的历史重要性将留给其他人来决定。
Summarizing the history of asthma over the life of the American Thoracic Society (ATS) is a challenging task. In 1904, when the Society began, the Index-Catalogue of the Surgeon General’s Office of the US Army (the Index Medicus of its time) listed 33 citations and 3 books on the subject. In contrast, 3,090 articles on asthma were published in 2000, and 191 new books were added to the Library of Congress. The story of such growth is worth the telling, for it represents clinical acumen at its best, blended with the avid use of emerging technologies, and therapeutic trial and error. Because the investigators were physicians, alleviating patient discomfort tended to take precedence over the need to understand causality and, as a result, some truly remarkable remedies were tried. It was not until the latter part of the twentieth century that advances in pathophysiology, immunobiology, and pharmacology began to be made in parallel and that solid understandings were achieved. This brief review attempts to present what was known when ATS started and how we arrived at where we are today. It deals primarily with events up through the last 15–20 years because such information is mature enough to have withstood the test of time. The most recent thoughts about asthma will be cataloged where appropriate, but their historical importance will be left to others to decide.